Experimental paracoccidioidomycosis of the Syrian hamster: fungicidal activity and production of inflammatory cytokines by macrophages

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dc.contributor.authorParise-Fortes, M. R.
dc.contributor.authorda Silva, MFP
dc.contributor.authorSugizaki, M. F.
dc.contributor.authorDefaveri, J.
dc.contributor.authorMontenegro, M. R.
dc.contributor.authorSoares, AMVC
dc.contributor.authorPeracoli, MTS
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:50:33Z
dc.date.available2014-05-20T13:50:33Z
dc.date.issued2000-02-01
dc.description.abstractPhagocytic cells play an important role in nonspecific resistance to fungal infection by mediating an inflammatory response and by a direct fungicidal action. In this study, the functional activity of peritoneal macrophages obtained from hamsters experimentally infected with strain Pb18 of Paracoccidioides brasiliensis was evaluated during 16 weeks of infection. The results showed that macrophages had a higher spreading ability associated with increased production of tumor necrosis factor alpha (TNF-alpha) and enhanced fungicidal activity during the early periods of infection. TNF-alpha levels remained elevated during all periods studied, while low levels of interleukin-1 beta (IL-1 beta) were produced during the infection. A necrotic area with dead fungi was observed at the inoculation site and the infection disseminated only to liver and lymph nodes in a few animals. These results suggest that during the early stages of infection with P. brasiliensis, macrophage activation by the high levels of TNF-alpha limited fungal dissemination. In contrast, in the later stages of infection, high levels of TNF-alpha were observed while the fungicidal activity of macrophages was lower and the animals presented loss of vitality resulting in their death. These observations suggest a complex role of TNF-alpha in experimental paracoccidioidomycosis of Syrian hamsters, involving not only resistance but also pathogenesis.en
dc.description.affiliationUniv Estadual Paulista, Dept Microbiol & Imunol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Sch Med, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Microbiol & Imunol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Med, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.format.extent51-60
dc.identifierhttp://www.ingentaconnect.com/content/apl/mmy/2000/00000038/00000001/art00009
dc.identifier.citationMedical Mycology. Oxford: B I O S Scientific Publishers Ltd, v. 38, n. 1, p. 51-60, 2000.
dc.identifier.doi10.1080/mmy.38.1.51.60
dc.identifier.issn1369-3786
dc.identifier.urihttp://hdl.handle.net/11449/18043
dc.identifier.wosWOS:000086247200009
dc.language.isoeng
dc.publisherB I O S Scientific Publishers Ltd
dc.relation.ispartofMedical Mycology
dc.relation.ispartofjcr2.799
dc.relation.ispartofsjr0,973
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjecthamsterspt
dc.subjectinterleukin-1pt
dc.subjectparacoccidioidomycosispt
dc.subjecttumor necrosis factorpt
dc.titleExperimental paracoccidioidomycosis of the Syrian hamster: fungicidal activity and production of inflammatory cytokines by macrophagesen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dcterms.rightsHolderB I O S Scientific Publishers Ltd
unesp.author.orcid0000-0002-0936-9512[7]
unesp.author.orcid0000-0003-1962-9901[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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