Effects of primovaccination and booster vaccination on serum cortisol and humoral immune response in cattle

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dc.contributor.authorReis, Luis S. L. S.
dc.contributor.authorPardo, Paulo E.
dc.contributor.authorFrazatti-Gallina, Neusa M.
dc.contributor.authorPaoli, Rosana L.
dc.contributor.authorOba, Eunice [UNESP]
dc.contributor.authorKronka, Sergio N. [UNESP]
dc.contributor.authorCamargos, Aline S. [UNESP]
dc.contributor.institutionUniversidade de Santo Amaro (UNISA)
dc.contributor.institutionUniversidade do Oeste Paulista (UNOESTE)
dc.contributor.institutionInstituto Butantan
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-04-01T18:44:10Z
dc.date.available2016-04-01T18:44:10Z
dc.date.issued2013
dc.description.abstractThe objective of this study was to evaluate the effect of one or two doses of the anti-rabies vaccination on the serum concentration of cortisol and the humoral immune response in cattle as well as the correlation between serum cortisol concentrations and the titers of rabies-neutralizing antibodies. Nelore cattle were randomly assigned to one of three groups, which were vaccinated with one dose of rabies vaccine (group GVSR, N = 15), two doses of rabies vaccine (group GVR, N = 15) or were not vaccinated (group Gc, N = 15). A commercial liquid inactivated rabies vaccine was used. The stressors imposed on the cattle were vaccination, corral handling and the presence of people. Blood samples were collected on days 0, 30 and 60 post-vaccination. Serum cortisol concentrations were determined using a solid-phase radioimmunoassay, and rabies antibody titers were determined using a serum neutralization test with BHK21 cells (RFFIT). Both serum cortisol concentrations and antibody titers increased after the second (booster) vaccination (P < 0.05). In all the groups, the serum cortisol concentrations increased after the cattle were handled in the corral (P < 0.05). No correlation was observed between the serum cortisol concentrations and the antibody titers with any treatment or on any observation day. In conclusion, booster vaccination is indispensable for primovaccinated cattle in achieving high and protective levels of rabies antibodies. Although booster vaccination and frequent cattle handling in corrals are stressors, the response is not strong enough to cause immunosuppression in cattle.en
dc.description.affiliationUniversidade de Santo Amaro, Department of Bromatology, Food and Animal Nutrition, São Paulo, Brazil
dc.description.affiliationUniversidade do Oeste Paulista, Department of Medical Clinic, Presidente Prudente, Brazil
dc.description.affiliationSection of Rabies of Instituto Butantan, São Paulo, Brazil
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Reprodução Animal e Radiologia Veterinária, Faculdade de Medicina Veterinária e Zootecnia de Botucatu, Botucatu, Distrito de Rubião Júnior, s/n, Rubião Júnior, CEP 18610250, SP, Brasil
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, Campus Jaboticabal, Brazil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Reprodução Animal e Radiologia Veterinária, Faculdade de Medicina Veterinária e Zootecnia de Botucatu, Botucatu, Distrito de Rubião Júnior, s/n, Rubião Júnior, CEP 18610250, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, Campus Jaboticabal, Brazil
dc.format.extent607-611
dc.identifierhttp://dx.doi.org/10.4236/abb.2013.45079
dc.identifier.citationAdvances in Bioscience and Biotechnology, v. 4, n. 5, p. 607-611, 2013.
dc.identifier.doi10.4236/abb.2013.45079
dc.identifier.fileISSN2156-8502-2013-04-05-607-611.pdf
dc.identifier.issn2156-8502
dc.identifier.lattes9224380586557664
dc.identifier.urihttp://hdl.handle.net/11449/137097
dc.language.isoeng
dc.relation.ispartofAdvances in Bioscience and Biotechnology
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectCattleen
dc.subjectStressen
dc.subjectStressoren
dc.subjectCortisolen
dc.subjectRabies vaccinationen
dc.subjectAntibodyen
dc.titleEffects of primovaccination and booster vaccination on serum cortisol and humoral immune response in cattleen
dc.typeArtigo
unesp.author.lattes9224380586557664
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt
unesp.departmentReprodução Animal e Radiologia Veterináriapt

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