Treatment of pulmonary thromboembolism in patients with systemic blood pressure stability and right ventricular dysfunction

Página do item simplificado
dc.contributor.authorYoo, Hugo Hyung Bok [UNESP]
dc.contributor.authorRodrigues, Haroldo [UNESP]
dc.contributor.authorQueluz, Thais Helena Abrahão Thomaz [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:48Z
dc.date.available2014-05-27T11:22:48Z
dc.date.issued2008-02-01
dc.description.abstractPulmonary thromboembolism (PTE) ranges from incidental, clinically unimportant thromboembolism to massive embolism with sudden death. Its treatment is well established in two groups of patients: heparin for those with normal systemic blood pressure without right ventricular dysfunction (RVD) and thrombolysis for those with RVD and circulatory shock. In an intermediate group of patients with systemic blood pressure stability combined with RVD, which is usually associated with worse outcome, the treatment is controversial. There are authors who strongly suggest thrombolysis while others contraindicate this procedure and recommend anticoagulation with heparin. This is a narrative review that includes clinical trials comparing thrombolysis and heparin for the treatment of PTE patients with systemic blood pressure stability and RVD published since 1973. The results show that there are only four trials on this subject with less than 500 patients. Many PTE patients with systemic blood pressure stability and RVD might benefit from thrombolysis but, on the other hand, the risk for hemorrhagic events may be increased. Large randomized clinical trials are required to clarify this. © 2008 Bentham Science Publishers Ltd.en
dc.description.affiliationPulmonary Division Botucatu Medical School Universidade Estadual Paulista (UNESP), Botucatu, SP 18618-970
dc.description.affiliationUnespPulmonary Division Botucatu Medical School Universidade Estadual Paulista (UNESP), Botucatu, SP 18618-970
dc.format.extent52-56
dc.identifierhttp://dx.doi.org/10.2174/157339808783497828
dc.identifier.citationCurrent Respiratory Medicine Reviews, v. 4, n. 1, p. 52-56, 2008.
dc.identifier.doi10.2174/157339808783497828
dc.identifier.issn1573-398X
dc.identifier.lattes3228294827229620
dc.identifier.scopus2-s2.0-39449103992
dc.identifier.urihttp://hdl.handle.net/11449/70299
dc.language.isoeng
dc.relation.ispartofCurrent Respiratory Medicine Reviews
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectPulmonary thromboembolism
dc.subjectRight ventricular dysfunction
dc.subjectSystemic blood pressure
dc.subjectThrombolysis
dc.subjectTreatment
dc.subjectalteplase
dc.subjectanticoagulant agent
dc.subjectantivitamin K
dc.subjectfibrinolytic agent
dc.subjectheparin
dc.subjectlow molecular weight heparin
dc.subjectnadroparin
dc.subjectstreptokinase
dc.subjecturokinase
dc.subjectwarfarin
dc.subjectbleeding
dc.subjectblood pressure monitoring
dc.subjectbrain hemorrhage
dc.subjectclinical trial
dc.subjectcombination chemotherapy
dc.subjectcontinuous infusion
dc.subjectdrug clearance
dc.subjectdrug contraindication
dc.subjectdrug efficacy
dc.subjectdrug indication
dc.subjectdrug metabolism
dc.subjectdrug response
dc.subjectdrug safety
dc.subjectdrug withdrawal
dc.subjectechocardiography
dc.subjectembolectomy
dc.subjectevidence based medicine
dc.subjectfibrinolytic therapy
dc.subjectgastrointestinal hemorrhage
dc.subjectheart dilatation
dc.subjectheart right ventricle failure
dc.subjecthemodynamic monitoring
dc.subjecthigh risk patient
dc.subjecthuman
dc.subjecthypotension
dc.subjectlung embolism
dc.subjectmonotherapy
dc.subjectoutcome assessment
dc.subjectpractice guideline
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectretroperitoneal hemorrhage
dc.subjectreview
dc.subjectrisk assessment
dc.subjectrisk benefit analysis
dc.subjectshock
dc.subjectsudden death
dc.subjectsurvival rate
dc.titleTreatment of pulmonary thromboembolism in patients with systemic blood pressure stability and right ventricular dysfunctionen
dc.typeResenha
dcterms.licensehttp://eurekaselect.com/209
unesp.author.lattes3228294827229620
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Coleções

Artigos - Clínica Médica - FMB