Bayesian genome-wide association analysis for body weight in farmed Atlantic salmon (Salmo salar L.)

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dc.contributor.authorYoshida, G. M. [UNESP]
dc.contributor.authorLhorente, J. P.
dc.contributor.authorCarvalheiro, R. [UNESP]
dc.contributor.authorYáñez, J. M.
dc.contributor.institutionUniversidad de Chile
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAquainnovo
dc.date.accessioned2018-12-11T17:15:25Z
dc.date.available2018-12-11T17:15:25Z
dc.date.issued2017-12-01
dc.description.abstractWe performed a genome-wide association study to detect markers associated with growth traits in Atlantic salmon. The analyzed traits included body weight at tagging (BWT) and body weight at 25 months (BW25M). Genotypes of 4662 animals were imputed from the 50K SNP chip to the 200K SNP chip using fimpute software. The markers were simultaneously modeled using Bayes C to identify genomic regions associated with the traits. We identified windows explaining a maximum of 3.71% and 3.61% of the genetic variance for BWT and BW25M respectively. We found potential candidate genes located within the top ten 1-Mb windows for BWT and BW25M. For instance, the vitronectin (VTN) gene, which has been previously reported to be associated with cell growth, was found within one of the top ten 1-Mb windows for BWT. In addition, the WNT1-inducible-signaling pathway protein 3, melanocortin 2 receptor accessory protein 2, myosin light chain kinase, transforming growth factor beta receptor type 3 and myosin light chain 1 genes, which have been reported to be associated with skeletal growth in humans, growth stimulation during the larval stage in zebrafish, body weight in pigs, feed conversion in chickens and growth rate of sheep skeletal muscle respectively, were found within some of the top ten 1-Mb windows for BW25M. These results indicate that growth traits are most likely controlled by many variants with relatively small effects in Atlantic salmon. The genomic regions associated with the traits studied here may provide further insight into the functional regions underlying growth traits in this species.en
dc.description.affiliationFacultad de Ciencias Veterinarias y Pecuarias Universidad de Chile, Av Santa Rosa 11735, La Pintana
dc.description.affiliationAnimal Science Department Faculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), Campus Jaboticabal, Via de Acesso Prof. Paulo Donato Castellane
dc.description.affiliationAquainnovo, Cardonal S/N
dc.description.affiliationUnespAnimal Science Department Faculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), Campus Jaboticabal, Via de Acesso Prof. Paulo Donato Castellane
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2014/20626-4
dc.description.sponsorshipIdFAPESP: 2015/25232-7
dc.description.sponsorshipIdCNPq: 308636/2014-7
dc.format.extent698-703
dc.identifierhttp://dx.doi.org/10.1111/age.12621
dc.identifier.citationAnimal Genetics, v. 48, n. 6, p. 698-703, 2017.
dc.identifier.doi10.1111/age.12621
dc.identifier.issn1365-2052
dc.identifier.issn0268-9146
dc.identifier.scopus2-s2.0-85031491388
dc.identifier.urihttp://hdl.handle.net/11449/175346
dc.language.isoeng
dc.relation.ispartofAnimal Genetics
dc.relation.ispartofsjr0,830
dc.relation.ispartofsjr0,830
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBayes C
dc.subjectgrowth
dc.subjectimputation
dc.subjectmyosin
dc.subjectsingle nucleotide polymorphism
dc.titleBayesian genome-wide association analysis for body weight in farmed Atlantic salmon (Salmo salar L.)en
dc.typeArtigo

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