Role of ticlopidine on adriamycin-induced nephropathy

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dc.contributor.authorRiyuzo, Márcia Camegaçava [UNESP]
dc.contributor.authorSoares, Vitor Augusto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:19:46Z
dc.date.available2014-05-27T11:19:46Z
dc.date.issued1999-10-11
dc.description.abstractThe effect of ticlopidine on rats with adriamycin nephropathy was observed during 26 weeks. In the ticlopidine-treated nephrotic animals (TNG), proteinuria was less than in the untreated nephrotic animals (NG), but this difference was significant only at week 6 (TNG = 47.27 ± 16.52 versus NG = 100.08 ± 13.83 mg/24h, p < 0.01) and week 26 (TNG = 157.00 ± 28.73 versus NG = 217.00 ± 21.73 mg/24h, p< 0.01) after ADR injection. NG presented severe tubulointerstitial abnormalities with a tubulointerstitial lesion index of 3+. No difference in glomerular lesions was observed among the groups (NG median = 6%, TNG median = 4% and TCG median = 2%). The tubulointerstitial lesion index of TNG was less intense (median = 2+) but not different from those of the control groups (CG median = 1+; TCG median = 0+) nor NG (median = 3+). We concluded that the treatment with ticlopidine produced some partially beneficial effects but did not prevent the development of adriamycin-induced nephropathy.en
dc.description.affiliationDepartamento de Pediatria Faculdade de Medicina Universidade Estadual Paulista, Botucatu, SP
dc.description.affiliationDepto. de Clinica Médica Faculdade de Medicina Universidade Estadual Paulista, Botucatu, SP
dc.description.affiliationDepartamento de Pediatria Faculdade de Medicina de Botucatu UNESP, P.O Box 541, Botucatu, SP, 18618-970
dc.description.affiliationUnespDepartamento de Pediatria Faculdade de Medicina Universidade Estadual Paulista, Botucatu, SP
dc.description.affiliationUnespDepto. de Clinica Médica Faculdade de Medicina Universidade Estadual Paulista, Botucatu, SP
dc.description.affiliationUnespDepartamento de Pediatria Faculdade de Medicina de Botucatu UNESP, P.O Box 541, Botucatu, SP, 18618-970
dc.format.extent469-475
dc.identifierhttp://dx.doi.org/10.3109/08860229909045185
dc.identifier.citationRenal Failure, v. 21, n. 5, p. 469-475, 1999.
dc.identifier.doi10.3109/08860229909045185
dc.identifier.issn0886-022X
dc.identifier.lattes1979519685789288
dc.identifier.scopus2-s2.0-0032878819
dc.identifier.urihttp://hdl.handle.net/11449/65862
dc.identifier.wosWOS:000083048800002
dc.language.isoeng
dc.relation.ispartofRenal Failure
dc.relation.ispartofjcr1.440
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAdriamycin nephropathy
dc.subjectAntiplatelet agent
dc.subjectProgression of renal disease
dc.subjectProteinuria
dc.subjectTiclopidine
dc.subjectdoxorubicin
dc.subjectticlopidine
dc.subjectanimal cell
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectdrug mechanism
dc.subjectinterstitial nephritis
dc.subjectintravenous drug administration
dc.subjectkidney disease
dc.subjectmale
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectproteinuria
dc.subjectrat
dc.subjectAnimals
dc.subjectAntibiotics, Antineoplastic
dc.subjectDoxorubicin
dc.subjectDrug Evaluation, Preclinical
dc.subjectKidney
dc.subjectMale
dc.subjectNephrosis
dc.subjectPlatelet Aggregation Inhibitors
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStatistics, Nonparametric
dc.subjectTime Factors
dc.titleRole of ticlopidine on adriamycin-induced nephropathyen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
unesp.author.lattes1979519685789288[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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