Low dose of cyclosporine A disrupts sperm parameters and testosterone levels reversibly in mice

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dc.contributor.authorSiervo, Gláucia Eloisa Munhoz de Lion
dc.contributor.authorMariani, Noemia Aparecida Partelli [UNESP]
dc.contributor.authorSilva, Alan Andrew S. [UNESP]
dc.contributor.authorPunhagui-Umbelino, Ana Paula Franco
dc.contributor.authorCosta, Ivana Regina da
dc.contributor.authorAndrade, Alexandre Dorth de [UNESP]
dc.contributor.authorSilva, Erick J.R. [UNESP]
dc.contributor.authorFernandes, Glaura Scantamburlo Alves
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:36:35Z
dc.date.available2023-07-29T13:36:35Z
dc.date.issued2023-02-01
dc.description.abstractThe prevalence of autoimmune diseases has increased worldwide, including in men of reproductive age. Cyclosporine A (CsA) is an immunosuppressive drug commonly used for long periods in the prophylaxis and treatment of autoimmune dysfunction and transplant rejection. Owing to CsA toxicity, most clinical settings use lower CsA doses. Therefore, we evaluated whether a low dose (10 mg/kg) of CsA affects sperm parameters (daily sperm production, motility, morphology, mitochondrial activity, and acrosomal integrity), plasma testosterone levels, and fertility after short-term (10 days) and long-term (50 days) treatments in mice. Short-term CsA treatment partially affected sperm parameters and fertility, as shown by the reduction in sperm hyperactivation and gestational rate 10 days after the interruption of short-term CsA treatment. Long-term CsA treatment impairs sperm count, hyperactivated motility, and acrosomal integrity. This treatment regimen further decreased plasma testosterone concentrations but did not affect reproductive outcomes in mating trials. These outcomes were reversed 50 days after the interruption of long-term CsA treatment. We conclude that a low CsA dose differentially impairs sperm parameters and testicular steroidogenesis in a time-dependent and mostly reversible manner but does not affect male fertility.en
dc.description.affiliationDepartment of General Biology Biological Sciences Center State University of Londrina (UEL), Londrina
dc.description.affiliationDepartment of Biophysics & Pharmacology Institute of Biosciences São Paulo State University (UNESP), Botucatu
dc.description.affiliationUnespDepartment of Biophysics & Pharmacology Institute of Biosciences São Paulo State University (UNESP), Botucatu
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.identifierhttp://dx.doi.org/10.1016/j.taap.2023.116374
dc.identifier.citationToxicology and Applied Pharmacology, v. 460.
dc.identifier.doi10.1016/j.taap.2023.116374
dc.identifier.issn1096-0333
dc.identifier.issn0041-008X
dc.identifier.scopus2-s2.0-85146132155
dc.identifier.urihttp://hdl.handle.net/11449/248177
dc.language.isoeng
dc.relation.ispartofToxicology and Applied Pharmacology
dc.sourceScopus
dc.subjectCalcineurin Inhibitor
dc.subjectImmunosuppressants
dc.subjectMouse
dc.subjectReproductive Toxicity
dc.subjectSperm Motility
dc.subjectSpermatozoa
dc.titleLow dose of cyclosporine A disrupts sperm parameters and testosterone levels reversibly in miceen
dc.typeArtigo

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