Healing, Antioxidant and Cytoprotective Properties of Indigofera truxillensis in Different Models of Gastric Ulcer in Rats

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dc.contributor.authorLuiz-Ferreira, Anderson
dc.contributor.authorCola, Maira
dc.contributor.authorBarbastefano, Victor
dc.contributor.authorde-Faria, Felipe Meira
dc.contributor.authorde Almeida, Ana Beatriz A.
dc.contributor.authorFarias-Silva, Elisangela
dc.contributor.authorCalvo, Tamara Regina [UNESP]
dc.contributor.authorHiruma-Lima, Clélia Akiko [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorSouza-Brito, Alba Regina M.
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:50:01Z
dc.date.available2014-05-20T13:50:01Z
dc.date.issued2012-11-01
dc.description.abstractThe present study evaluated the antiulcerogenic activity and mechanisms of the aqueous (AqF 100 mg/kg) and ethyl acetate (AcF 50 mg/kg) fractions from Indigofera truxillensis leaves. This dose was selected to assess its activity on ulcer healing and its action on gastric acid and mucus secretion, prostaglandin production and antioxidant enzyme activity (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd)). Gastric ulcer was induced by absolute ethanol. Antisecretory action, mucus and prostaglandin production, healing and antioxidant enzyme activities were evaluated for both fractions. AqF and AcF significantly inhibited the gastric mucosal damage caused by ethanol. This effect was statistically significant at 100 and 50 mg/kg compared with the vehicle. Neither fraction interfered with gastric secretion. AcF increased the PGE(2) production, and both fractions increased mucus production. L-NAME did not alter the gastroprotection exerted by the fractions, but N-ethylmaleimide attenuated only AcF. In the ischemia/reperfusion model both fractions inhibited the mucosal damage. AcF increased SOD, GSH-Px and GSH-Rd activity, but AqF increased only SOD and GSH-Px. In the acetic acid-induced ulcer model AcF only accelerated ulcer healing. These results showed that Indigofera truxillensis acted as a gastroprotective agent, stimulating protective factors and antioxidants enzymes.en
dc.description.affiliationUniv Fed Goias, Dept Biol Sci, BR-75704020 Catalao, Go, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Struct & Funct Biol, Inst Biol, BR-13083865 São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Pharmacol, Fac Med Sci, BR-13083887 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Organ Chem, Inst Chem, BR-14800900 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Physiol, Inst Biosci, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Organ Chem, Inst Chem, BR-14800900 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Physiol, Inst Biosci, BR-18618000 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent14973-14991
dc.identifierhttp://dx.doi.org/10.3390/ijms131114973
dc.identifier.citationInternational Journal of Molecular Sciences. Basel: Mdpi Ag, v. 13, n. 11, p. 14973-14991, 2012.
dc.identifier.doi10.3390/ijms131114973
dc.identifier.fileWOS000311425000075.pdf
dc.identifier.issn1422-0067
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/17836
dc.identifier.wosWOS:000311425000075
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.ispartofjcr3.687
dc.relation.ispartofsjr1,260
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectIndigofera truxillensisen
dc.subjectgastric ulceren
dc.subjectmedicinal plantsen
dc.subjectantioxidant enzymesen
dc.titleHealing, Antioxidant and Cytoprotective Properties of Indigofera truxillensis in Different Models of Gastric Ulcer in Ratsen
dc.typeArtigo
dcterms.licensehttp://www.mdpi.com/about/openaccess
dcterms.rightsHolderMdpi Ag
unesp.author.lattes3814504901386844[8]
unesp.author.orcid0000-0002-8645-3777[8]
unesp.author.orcid0000-0003-3032-2556[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Química Orgânica - IQ