Cytological and cytomorphometric evaluation of the oral mucosa in HIV-infected patients undergoing antiretroviral therapy

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dc.contributor.authorAlves, Mônica Ghislaine Oliveira [UNESP]
dc.contributor.authorLima Carta, Celina Faig [UNESP]
dc.contributor.authorBrandão, Adriana Aigotti Haberbeck [UNESP]
dc.contributor.authorFurtado, Juvencio José Duailibe
dc.contributor.authorMarcucci, Marcelo
dc.contributor.authorAlmeida, Janete Dias [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Braz Cubas
dc.contributor.institutionHeliopolis Hospital
dc.date.accessioned2018-12-11T17:32:33Z
dc.date.available2018-12-11T17:32:33Z
dc.date.issued2017-10-01
dc.description.abstractBackground: To evaluate HIV infection-induced alterations in the oral mucosa by comparing inflammation, cell maturation, and cytomorphometric changes in oral mucosal cells between HIV-infected patients undergoing highly active antiretroviral therapy (HAART) and non-HIV-infected patients. Methods: Thirty HIV-infected patients undergoing HAART and 30 non-HIV-infected patients were studied. Four smears were obtained from the lateral border of the tongue and floor of the mouth with a cytobrush. One sample was stained by the Papanicolaou technique, and three samples were processed for Feulgen staining. Papanicolaou-stained smears were analyzed by light microscopy, and the cytoplasmic (CA) and nuclear (NA) area were measured with the Software AxioVision 4.7. Results: The Wilcoxon signed-rank test showed a significant difference in intermediate epithelial cell types between the HIV-infected and non-HIV-infected groups (P=.005). However, this difference was not observed for superficial epithelial cell types with (P=.672) and without a nucleus (P=.069). Comparative analysis revealed no significant difference in CA (P=.604), NA (P=.298) or NA/CA (P=.456) between the HIV-infected and non-HIV-infected groups. Keratohyalin granules were more frequent in the non-HIV-infected group (P=.0001). Conclusions: The results showed alterations in cell maturation in HIV-infected patients undergoing HAART with undetectable viral load, but no morphometric changes were observed.en
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)
dc.description.affiliationSchool of Dentistry Universidade Braz Cubas
dc.description.affiliationDepartment of Infectious Diseases Heliopolis Hospital
dc.description.affiliationDepartment of Stomatology and Maxillofacial Surgery Heliopolis Hospital
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/05062-1
dc.format.extent840-845
dc.identifierhttp://dx.doi.org/10.1111/jop.12590
dc.identifier.citationJournal of Oral Pathology and Medicine, v. 46, n. 9, p. 840-845, 2017.
dc.identifier.doi10.1111/jop.12590
dc.identifier.issn1600-0714
dc.identifier.issn0904-2512
dc.identifier.scopus2-s2.0-85019666488
dc.identifier.urihttp://hdl.handle.net/11449/178886
dc.language.isoeng
dc.relation.ispartofJournal of Oral Pathology and Medicine
dc.relation.ispartofsjr0,791
dc.relation.ispartofsjr0,791
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjecthighly active antiretroviral therapy
dc.subjectHIV infection
dc.subjectoral cytology
dc.subjectoral pathology
dc.titleCytological and cytomorphometric evaluation of the oral mucosa in HIV-infected patients undergoing antiretroviral therapyen
dc.typeArtigo
unesp.author.orcid0000-0002-3411-9443[1]
unesp.author.orcid0000-0002-9305-079X[2]

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