Guttiferones: An insight into occurrence, biosynthesis, and their broad spectrum of pharmacological activities

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dc.contributor.authorConceição, Mariana [UNESP]
dc.contributor.authorBeserra, Fernando Pereira [UNESP]
dc.contributor.authorAldana Mejia, Jennyfer Andrea
dc.contributor.authorCaldas, Gabriel Rocha
dc.contributor.authorTanimoto, Matheus Hikaru
dc.contributor.authorLuzenti, Andréia Marincek
dc.contributor.authorGaspari, Priscyla Daniely Marcato
dc.contributor.authorEvans, Nicholas David
dc.contributor.authorBastos, Jairo Kenupp
dc.contributor.authorPellizzon, Cláudia Helena [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionSouthampton General Hospital
dc.date.accessioned2023-07-29T16:01:31Z
dc.date.available2023-07-29T16:01:31Z
dc.date.issued2023-01-25
dc.description.abstractGuttiferones belong to the polyisoprenylated benzophenone, a class of compounds, a very restricted group of natural plant products, especially in the Clusiaceae family. They are commonly found in bark, stem, leaves, and fruits of plants of the genus Garcinia and Symphonia. Guttiferones have the following classifications according to their chemical structure: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, and T. All of them have received growing attention due to its multiple biological activities. This review provides a first comprehensive approach to plant sources, phytochemical profile, specific pharmacological effects, and mechanisms of guttiferones already described. Studies indicate a broad spectrum of pharmacological activities, such as: anti-inflammatory, immunomodulatory, antioxidant, antitumor, antiparasitic, antiviral, and antimicrobial. Despite the low toxicity of these compounds in healthy cells, there is a lack of studies in the literature related to toxicity in general. Given their beneficial effects, guttiferones are expected to be great potential drug candidates for treating cancer and infectious and transmissible diseases. However, further studies are needed to elucidate their toxicity, specific molecular mechanisms and targets, and to perform more in-depth pharmacokinetic studies. This review highlights chemical properties, biological characteristics, and mechanisms of action so far, offering a broad view of the subject and perspectives for the future of guttiferones in therapeutics.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), Botucatu
dc.description.affiliationDepartment of Pharmaceutical Sciences School of Pharmaceutical Sciences University of São Paulo (USP), SP
dc.description.affiliationHuman Development and Health University of Southampton Faculty of Medicine Southampton General Hospital
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), Botucatu
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2017/04138–8
dc.description.sponsorshipIdFAPESP: 2021/01258–8
dc.identifierhttp://dx.doi.org/10.1016/j.cbi.2022.110313
dc.identifier.citationChemico-Biological Interactions, v. 370.
dc.identifier.doi10.1016/j.cbi.2022.110313
dc.identifier.issn1872-7786
dc.identifier.issn0009-2797
dc.identifier.scopus2-s2.0-85144792388
dc.identifier.urihttp://hdl.handle.net/11449/249505
dc.language.isoeng
dc.relation.ispartofChemico-Biological Interactions
dc.sourceScopus
dc.subjectBenzophenone
dc.subjectEffects
dc.subjectGuttiferones
dc.subjectMechanisms
dc.subjectSynthesis
dc.titleGuttiferones: An insight into occurrence, biosynthesis, and their broad spectrum of pharmacological activitiesen
dc.typeResenha
unesp.author.orcid0000-0003-4398-1817[1]

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