Bacterial identification in cerebrospinal fluid of domestic species with neurologic signs: a retrospective case-series study in 136 animals (2005–2021)

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dc.contributor.authorRibeiro, Márcio Garcia [UNESP]
dc.contributor.authorPereira, Thiago Tourinho [UNESP]
dc.contributor.authorde Lima Paz, Patrik Júnior [UNESP]
dc.contributor.authorde Almeida, Beatriz Oliveira [UNESP]
dc.contributor.authorCerviño, Carmen S. Araújo [UNESP]
dc.contributor.authorRodrigues, Carolina Aparecida [UNESP]
dc.contributor.authorSantos, Gabrielly Terra Sartori [UNESP]
dc.contributor.authorde Souza Freire, Larissa Maria [UNESP]
dc.contributor.authorPortilho, Fábio Vinicius Ramos [UNESP]
dc.contributor.authorFilho, Marcelo Fagali Árabe [UNESP]
dc.contributor.authorPaschoal, Natália Rodrigues [UNESP]
dc.contributor.authorBello, Thaís Spessotto [UNESP]
dc.contributor.authorMegid, Jane [UNESP]
dc.contributor.authorLangoni, Helio [UNESP]
dc.contributor.authorAppolinário, Camila Michele [UNESP]
dc.contributor.authorBorges, Alexandre Secorun [UNESP]
dc.contributor.authorAmorim, Rogério Martins [UNESP]
dc.contributor.authorGiuffrida, Rogério
dc.contributor.authorde Oliveira Filho, José Paes [UNESP]
dc.contributor.authorSiqueira, Amanda Keller
dc.contributor.authorListoni, Fernando José Paganini [UNESP]
dc.contributor.authorPaes, Antonio Carlos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Western São Paulo - UNOESTE
dc.contributor.institutionMidwestern State University - UNICENTRO
dc.date.accessioned2023-07-29T13:34:21Z
dc.date.available2023-07-29T13:34:21Z
dc.date.issued2023-03-01
dc.description.abstractCentral nervous system (CNS) infections comprise life-threatening clinical conditions in domestic species, and are commonly related to severe sequelae, disability, or high fatality rates. A set of bacterial pathogens have been identified in central nervous infections in livestock and companion animals, although the most of descriptions are restricted to case reports and a lack of comprehensive studies involving CNS-related bacterial infections have been focused on a great number of domestic species. In this scenario, we retrospectively investigated selected epidemiological data, clinical findings, bacteriological culture, and in vitro susceptibility patterns of 136 nonrepetitive neurologic cases in domestic species (2005–2021). Bacterial isolates were recovered from 25% (34/136) of the cerebrospinal fluid (CSF) sampled. The isolates were obtained from cattle (9/136 = 6.6%), dogs (7/136 = 5.1%), horses (6/136 = 4.4%), goats (3/136 = 2.2%), pigs (3/136 = 2.2%), sheep (3/136 = 2.2%), cats (2/136 = 1.5%), and asinine (1/136 = 0.7%). Among animals with bacterial isolation, Staphylococcus aureus (6/34 = 17.6%), Escherichia coli (5/34 = 14.7%), Staphylococcus beta-hemolytic (5/34 = 14.7%), and Trueperella pyogenes (3/34 = 8.8%) were predominant, in addition to a miscellaneous of other bacteria isolated in minor frequency, e.g., Corynebacterium pseudotuberculosis, Enterobacter cloacae, Mannheimia haemolytica, Pseudomonas aeruginosa, and Streptococcus equi subsp. equi. In vitro susceptibility tests of isolates revealed that amoxicillin/clavulanic acid (11/13 = 84.6%), cephalexin (9/11 = 81.8%), and florfenicol (9/12 = 75%) were the most effective antimicrobials. Conversely, isolates exhibited resistance mainly to tetracycline (6/10 = 60%), penicillin (6/11 = 54.5%), and trimethoprim/sulfamethoxazole (5/11 = 45.5%). Also, multidrug resistance to ≥ 3 classes of antimicrobials was found in 23.5% (8/34) strains. Data relative to the outcome was available in 79.4% (27/34) of animals that had bacterial isolation, and from these, the lethality rate was 92.6% (25/27). Incoordination (14/34 = 41.2%), recumbency (11/34 = 32.4%), apathy (10/34 = 29.4%), anorexia (9/34 = 26.5%), blindness (7/34 = 20.6%), seizure (6/34 = 17.6%), limb paresis (5/34 = 14.7%), head-pressing (4/34 = 11.8%), and nystagmus (3/34 = 8.8%) were the most frequent clinical signs. A variety of bacterial pathogens were identified in the CSF of domestic species showing neurologic signs, with a predominance of staphylococci, streptococci, and enterobacteria. High lethality of cases, poor in vitro efficacy of conventional antimicrobials, and a high in vitro multidrug resistance pattern of isolates were seen. Our results contribute to etiological characterization, antimicrobial resistance patterns, and clinical-epidemiological findings of bacterial infections in domestic species with neurological signs.en
dc.description.affiliationDepartment of Animal Production and Preventive Veterinary Medicine Faculty of Veterinary Medicine and Animal Sciences - FMVZ Sao Paulo State University - UNESP, SP
dc.description.affiliationSchool of Veterinary Medicine and Animal Science São Paulo State University (UNESP), SP
dc.description.affiliationSchool of Veterinary Medicine University of Western São Paulo - UNOESTE, SP
dc.description.affiliationSchool of Veterinary Medicine Midwestern State University - UNICENTRO, PR
dc.description.affiliationUnespDepartment of Animal Production and Preventive Veterinary Medicine Faculty of Veterinary Medicine and Animal Sciences - FMVZ Sao Paulo State University - UNESP, SP
dc.description.affiliationUnespSchool of Veterinary Medicine and Animal Science São Paulo State University (UNESP), SP
dc.format.extent449-457
dc.identifierhttp://dx.doi.org/10.1007/s42770-022-00891-2
dc.identifier.citationBrazilian Journal of Microbiology, v. 54, n. 1, p. 449-457, 2023.
dc.identifier.doi10.1007/s42770-022-00891-2
dc.identifier.issn1678-4405
dc.identifier.issn1517-8382
dc.identifier.scopus2-s2.0-85144874629
dc.identifier.urihttp://hdl.handle.net/11449/248097
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Microbiology
dc.sourceScopus
dc.subjectBacterial etiology
dc.subjectCentral nervous infections
dc.subjectCompanion animals
dc.subjectLivestock
dc.subjectMultidrug resistance
dc.titleBacterial identification in cerebrospinal fluid of domestic species with neurologic signs: a retrospective case-series study in 136 animals (2005–2021)en
dc.typeArtigo
unesp.author.orcid0000-0003-2682-9389[1]

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