Review of Properties and Analytical Methods for the Determination of Norfloxacin

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dc.contributor.authorChierentin, Lucas [UNESP]
dc.contributor.authorNunes Salgado, Herida Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-27T08:57:07Z
dc.date.available2018-11-27T08:57:07Z
dc.date.issued2016-01-02
dc.description.abstractThe first-generation quinolones have their greatest potency against Gram-negative bacteria, but newly developed molecules have exhibited increased potency against Gram-positive bacteria, and existing agents are available with additional activity against anaerobic microorganisms. Norfloxacin is a broad-spectrum antimicrobial fluoroquinolone used against Gram-positive and Gram-negative organisms (aerobic organisms). There are different analytical methods available to determine norfloxacin applied in quality control of this medicine in order to ensure its effectiveness and safety. The authors present an overview of the fourth generation of quinolones, followed by the properties, applications, and analytical methods of norfloxacin. These results show several existing analytical techniques that are flexible and broad-based methods of analysis in different matrices. This article focuses on bionalytical and pharmaceutical quality-control applications, such as thin-layer chromatography, microbiological assay, spectrophotometry, capillary electrophoresis (CE), and high-performance liquid chromatography (HPLC).en
dc.description.affiliationSao Paulo State Univ, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent22-39
dc.identifierhttp://dx.doi.org/10.1080/10408347.2014.941456
dc.identifier.citationCritical Reviews In Analytical Chemistry. Philadelphia: Taylor & Francis Inc, v. 46, n. 1, p. 22-39, 2016.
dc.identifier.doi10.1080/10408347.2014.941456
dc.identifier.fileWOS000370298000003.pdf
dc.identifier.issn1040-8347
dc.identifier.urihttp://hdl.handle.net/11449/165067
dc.identifier.wosWOS:000370298000003
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofCritical Reviews In Analytical Chemistry
dc.relation.ispartofsjr0,819
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAnalytical methods
dc.subjectnorfloxacin
dc.subjectfluoroquinolones
dc.subjectquality control
dc.subjectpharmacokinetics
dc.titleReview of Properties and Analytical Methods for the Determination of Norfloxacinen
dc.typeResenha
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.orcid0000-0002-7683-7363[1]

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Artigos - Fármacos e Medicamentos - FCFAR