Plasma matrix metalloproteinase-9 levels, MMP-9 gene haplotypes, and cardiovascular risk in obese subjects

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dc.contributor.authorLuizon, Marcelo R. [UNESP]
dc.contributor.authorBelo, Vanessa A.
dc.contributor.authorFernandes, Karla S.
dc.contributor.authorAndrade, Vanessa L.
dc.contributor.authorTanus-Santos, Jose E.
dc.contributor.authorSandrim, Valeria C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionSanta Casa de Belo Horizonte
dc.date.accessioned2018-12-11T17:02:47Z
dc.date.available2018-12-11T17:02:47Z
dc.date.issued2016-06-01
dc.description.abstractPlasma matrix metalloproteinase (MMP)-9 is a predictor of cardiovascular mortality, and MMP-9 polymorphisms affect plasma MMP-9 levels. However, no study examined whether MMP-9 haplotypes affect MMP-9 levels in obese adults. We examined whether MMP-9 polymorphisms and haplotypes are associated with obesity, and whether they affect MMP-9 levels in obese subjects. We examined the plasma levels of MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 in 105 subjects with normal weight (controls), 100 obese subjects, and 156 obese subjects with ≥3 metabolic risk factors (MRFs). We determined genotypes for three polymorphisms: C-1562T (rs3918242), Q279R (A>G, rs17576), and R668Q (G>A, rs17577). MMP-9 levels and activity (MMP-9/TIMP-1 ratio) were higher in obese subjects than in controls (P < 0.05). However, MMP-9 levels were higher in obese subjects with ≥3 MRFs than in obese subjects (P < 0.05). Obese subjects with ≥3 MRFs carrying the GA+AA genotypes for R668Q (G>A) polymorphism had higher MMP-9 levels than subjects carrying the AA genotype (P < 0.05). The “T, G, A” haplotype was more common in both groups of obese subjects than in controls (OR 3.95 and 4.39, respectively; P < 0.01). Notably, obese subjects with ≥3 MRFs carrying the “T, G, A” haplotype had higher MMP-9 levels than subjects carrying the “C, A, G” reference haplotype (P < 0.05). The “T, G, A” haplotype was associated with an increased risk of obesity and affected MMP-9 levels in obese subjects with ≥3 MRFs. Our findings suggest that plasma MMP-9 levels and MMP-9 haplotypes may help to discriminate obese subjects at an increased cardiovascular risk.en
dc.description.affiliationDepartment of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP), Distrito de Rubião Junior S/N
dc.description.affiliationDepartment of Pharmacology Ribeirao Preto Medical School University of São Paulo, Av. Bandeirantes, 3900
dc.description.affiliationNúcleo de Pós-graduação e Pesquisa Santa Casa de Belo Horizonte, Rua Domingos Vieira, 590
dc.description.affiliationUnespDepartment of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP), Distrito de Rubião Junior S/N
dc.format.extent463-471
dc.identifierhttp://dx.doi.org/10.1007/s11033-016-3993-z
dc.identifier.citationMolecular Biology Reports, v. 43, n. 6, p. 463-471, 2016.
dc.identifier.doi10.1007/s11033-016-3993-z
dc.identifier.file2-s2.0-84966441164.pdf
dc.identifier.issn1573-4978
dc.identifier.issn0301-4851
dc.identifier.scopus2-s2.0-84966441164
dc.identifier.urihttp://hdl.handle.net/11449/172933
dc.language.isoeng
dc.relation.ispartofMolecular Biology Reports
dc.relation.ispartofsjr0,721
dc.relation.ispartofsjr0,721
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectHaplotypes
dc.subjectMatrix metalloproteinase (MMP)-9
dc.subjectMetabolic risk factors
dc.subjectObesity
dc.subjectPolymorphisms
dc.subjectTissue inhibitor of matrix metalloproteinase (TIMP)-1
dc.titlePlasma matrix metalloproteinase-9 levels, MMP-9 gene haplotypes, and cardiovascular risk in obese subjectsen
dc.typeArtigo

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