Plasma matrix metalloproteinase-9 levels, MMP-9 gene haplotypes, and cardiovascular risk in obese subjects
dc.contributor.author | Luizon, Marcelo R. [UNESP] | |
dc.contributor.author | Belo, Vanessa A. | |
dc.contributor.author | Fernandes, Karla S. | |
dc.contributor.author | Andrade, Vanessa L. | |
dc.contributor.author | Tanus-Santos, Jose E. | |
dc.contributor.author | Sandrim, Valeria C. [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Santa Casa de Belo Horizonte | |
dc.date.accessioned | 2018-12-11T17:02:47Z | |
dc.date.available | 2018-12-11T17:02:47Z | |
dc.date.issued | 2016-06-01 | |
dc.description.abstract | Plasma matrix metalloproteinase (MMP)-9 is a predictor of cardiovascular mortality, and MMP-9 polymorphisms affect plasma MMP-9 levels. However, no study examined whether MMP-9 haplotypes affect MMP-9 levels in obese adults. We examined whether MMP-9 polymorphisms and haplotypes are associated with obesity, and whether they affect MMP-9 levels in obese subjects. We examined the plasma levels of MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 in 105 subjects with normal weight (controls), 100 obese subjects, and 156 obese subjects with ≥3 metabolic risk factors (MRFs). We determined genotypes for three polymorphisms: C-1562T (rs3918242), Q279R (A>G, rs17576), and R668Q (G>A, rs17577). MMP-9 levels and activity (MMP-9/TIMP-1 ratio) were higher in obese subjects than in controls (P < 0.05). However, MMP-9 levels were higher in obese subjects with ≥3 MRFs than in obese subjects (P < 0.05). Obese subjects with ≥3 MRFs carrying the GA+AA genotypes for R668Q (G>A) polymorphism had higher MMP-9 levels than subjects carrying the AA genotype (P < 0.05). The “T, G, A” haplotype was more common in both groups of obese subjects than in controls (OR 3.95 and 4.39, respectively; P < 0.01). Notably, obese subjects with ≥3 MRFs carrying the “T, G, A” haplotype had higher MMP-9 levels than subjects carrying the “C, A, G” reference haplotype (P < 0.05). The “T, G, A” haplotype was associated with an increased risk of obesity and affected MMP-9 levels in obese subjects with ≥3 MRFs. Our findings suggest that plasma MMP-9 levels and MMP-9 haplotypes may help to discriminate obese subjects at an increased cardiovascular risk. | en |
dc.description.affiliation | Department of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP), Distrito de Rubião Junior S/N | |
dc.description.affiliation | Department of Pharmacology Ribeirao Preto Medical School University of São Paulo, Av. Bandeirantes, 3900 | |
dc.description.affiliation | Núcleo de Pós-graduação e Pesquisa Santa Casa de Belo Horizonte, Rua Domingos Vieira, 590 | |
dc.description.affiliationUnesp | Department of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP), Distrito de Rubião Junior S/N | |
dc.format.extent | 463-471 | |
dc.identifier | http://dx.doi.org/10.1007/s11033-016-3993-z | |
dc.identifier.citation | Molecular Biology Reports, v. 43, n. 6, p. 463-471, 2016. | |
dc.identifier.doi | 10.1007/s11033-016-3993-z | |
dc.identifier.file | 2-s2.0-84966441164.pdf | |
dc.identifier.issn | 1573-4978 | |
dc.identifier.issn | 0301-4851 | |
dc.identifier.scopus | 2-s2.0-84966441164 | |
dc.identifier.uri | http://hdl.handle.net/11449/172933 | |
dc.language.iso | eng | |
dc.relation.ispartof | Molecular Biology Reports | |
dc.relation.ispartofsjr | 0,721 | |
dc.relation.ispartofsjr | 0,721 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | Haplotypes | |
dc.subject | Matrix metalloproteinase (MMP)-9 | |
dc.subject | Metabolic risk factors | |
dc.subject | Obesity | |
dc.subject | Polymorphisms | |
dc.subject | Tissue inhibitor of matrix metalloproteinase (TIMP)-1 | |
dc.title | Plasma matrix metalloproteinase-9 levels, MMP-9 gene haplotypes, and cardiovascular risk in obese subjects | en |
dc.type | Artigo |
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