Padronização dos critérios de seleção em estudos sobre medicações nasais
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Data
2009-12-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
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Tipo
Artigo
Direito de acesso
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Resumo
Clinical studies on nasal topical medications require the standardization of nasosinusal normality in order to establish control groups through a specific evaluation of the upper airways. Aim: to standardize the evaluation of candidates for control groups in clinical studies on nasal topical medications. Material and Methods: healthy male volunteers of 18 to 50 years of age, asymptomatic from the nasosinusal standpoint were subjected to a sequential and excluding assessment made up of clinical evaluation, immediate hypersensitivity skin test, saccharin test, flexible nasofibroscopy and nasal cytology. Study design: Crosssectional contemporary cohort. Results: Of the 33 people originally enrolled, 14 (42.4%) were excluded for clinical reasons. Of the 19 remaining, 2 (10.5%) had atopy diagnosed in the skin test and were excluded. 17 were tested with saccharin and presented normal mucociliary clearance. Evaluation by nasal endoscopy showed abnormality in 2 cases (11.8%) and these were excluded. The remaining 15 were submitted to nasal cytology, which proved normal, representing 45.5% of those initially included. Conclusion: The proposed protocol for sequential and excluding evaluation was effective in defining candidates for the establishment of control groups in clinical studies on nasal topical medications. © Revista Brasileira de Otorrinolaringologia. All Rights reserved.
Descrição
Palavras-chave
Control groups , Cytology , Mucociliary clearance , Nose , Skin tests , diagnostic agent , saccharin , adolescent , adult , case control study , cross-sectional study , human , immediate type hypersensitivity , intranasal drug administration , male , middle aged , mucociliary clearance , patient selection , skin test , Administration, Intranasal , Adolescent , Adult , Case-Control Studies , Cross-Sectional Studies , Humans , Hypersensitivity, Immediate , Male , Middle Aged , Mucociliary Clearance , Patient Selection , Saccharin , Skin Tests , Young Adult
Idioma
Português
Como citar
Brazilian Journal of Otorhinolaryngology, v. 75, n. 6, 2009.