Aromatase inhibitors in the treatment of oligozoospermic or azoospermic men: A systematic review of randomized controlled trials

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dc.contributor.authorRibeiro, Mariana Antunes [UNESP]
dc.contributor.authorGameiro, Luís F. O. [UNESP]
dc.contributor.authorScarano, Wellerson R. [UNESP]
dc.contributor.authorBriton-Jones, Christine
dc.contributor.authorKapoor, Anil
dc.contributor.authorRosa, Mauro B.
dc.contributor.authorEl Dib, Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionReproductive Medicine Partners of New York
dc.contributor.institutionJuravinski Cancer Centre
dc.contributor.institutionSt. Joseph’s Healthcare
dc.contributor.institutionHospital do Coração (HCOR)
dc.date.accessioned2018-12-11T17:02:54Z
dc.date.available2018-12-11T17:02:54Z
dc.date.issued2016-01-01
dc.description.abstractThe aim of this study as to analyze published evidence regarding the effectiveness of aromatase inhibitor therapy on improving spermatogenesis in infertile men. We carried out a systematic review of randomized controlled trials. The date of the most recent search was October 4, 2015. Two authors independently selected relevant clinical trials, assessing their methodological quality and extracting data. Three studies were included in this review with a total of 100 participants; however, we were able to include data from only 54 participants in the analysis. In the representation of meta-analysis with a single study comparing testolactone versus placebo, related to the hormone concentrations, there was a statistically significance difference favoring the use of testolactone for Luteinizing Hormone (LH); Estrogen (E2); free Testosterone (free T); free Estrogen (free E2); 17-Hydroxyprogesterone (17OHP); prolactin (PRL). In another analysis from a single study comparing letrozole versus anastrozole, there was also a statistically significance difference favoring the use of letrozole for the increase in both the sperm count and LH. There is only low quality evidence regarding the effectiveness of aromatase inhibitor therapy in infertile men. Further trials are needed with standardized interventions and outcomes.en
dc.description.affiliationDepartment of Morphology Institute of Biosciences Sao Paulo State University UNESP
dc.description.affiliationPhysiotherapy Service School of Medicine Sao Paulo State University UNESP
dc.description.affiliationReproductive Medicine Partners of New York
dc.description.affiliationJuravinski Cancer Centre
dc.description.affiliationMcMaster Institute of Urology St. Joseph’s Healthcare
dc.description.affiliationHospital do Coração (HCOR)
dc.description.affiliationDepartment of Anesthesiology Faculdade de Medicina de Botucatu (FMB) Sao Paulo State University UNESP
dc.description.affiliationUnespDepartment of Morphology Institute of Biosciences Sao Paulo State University UNESP
dc.description.affiliationUnespPhysiotherapy Service School of Medicine Sao Paulo State University UNESP
dc.description.affiliationUnespDepartment of Anesthesiology Faculdade de Medicina de Botucatu (FMB) Sao Paulo State University UNESP
dc.format.extent82-88
dc.identifierhttp://dx.doi.org/10.5935/1518-0557.20160019
dc.identifier.citationJornal Brasileiro de Reproducao Assistida, v. 20, n. 2, p. 82-88, 2016.
dc.identifier.doi10.5935/1518-0557.20160019
dc.identifier.issn1518-0557
dc.identifier.issn1517-5693
dc.identifier.scopus2-s2.0-84969246776
dc.identifier.urihttp://hdl.handle.net/11449/172961
dc.language.isoeng
dc.relation.ispartofJornal Brasileiro de Reproducao Assistida
dc.relation.ispartofsjr0,282
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAromatase inhibitors
dc.subjectInfertile men
dc.subjectMeta-analysis
dc.subjectSpermatogenesis
dc.titleAromatase inhibitors in the treatment of oligozoospermic or azoospermic men: A systematic review of randomized controlled trialsen
dc.typeResenha

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