Evaluation of TFAM and FABP4 gene polymorphisms in three lines of Nellore cattle selected for growth

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dc.contributor.authorAyres, D. R. [UNESP]
dc.contributor.authorSouza, F. R. P. [UNESP]
dc.contributor.authorMercadante, M. E. Z.
dc.contributor.authorFonseca, L. F. S. [UNESP]
dc.contributor.authorTonhati, Humberto [UNESP]
dc.contributor.authorCyrillo, J. N. S. G.
dc.contributor.authorBonilha, Sarah Figueiredo Martins
dc.contributor.authorAlbuquerque, Lucia Galvão de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:19:10Z
dc.date.available2014-05-20T13:19:10Z
dc.date.issued2010-01-01
dc.description.abstractWe analyzed the polymorphisms TFAM HaeIII, TFAM MboI and FABP4 MspA1I in three Nellore lines selected for growth in order to evaluate how selection affects the frequencies of these polymorphisms and evaluate their association with growth and carcass traits in Zebu cattle. Birth, weaning and yearling weights, rump height, longissimus muscle area, backfat thickness, and rump fat thickness were analyzed. The sample was constituted of animals from two lines selected for yearling weight (NeS and NeT), and a control line (NeC), established in 1980, at the São Paulo Instituto de Zootecnia. Two hundred and seventy-two heifers were genotyped for TFAM gene SNPs, and 325 heifers were genotyped for the FABP4 SNP. High frequencies were observed for the alleles A (TFAM HaeIII), C (TFAM MboI) and C (FABP4 MspA1I). Significant differences in allele frequencies between NeS and NeT were observed for the TFAM HaeIII, and between the line NeT and lines NeC and NeS for the FABP4 MspA1I SNP. Five haplotypes were observed for the two polymorphisms in the TFAM gene, haplotype AACC being the most frequent. None of the markers evaluated separately or according to haplotype was significantly associated with the growth and carcass traits. The low frequencies of alleles that are associated with high marbling scores and thick subcutaneous fat in taurine breeds might explain the low means for these traits in Nellore cattle.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Agr & Vet, Dept Zootecnia, Jaboticabal, SP, Brazil
dc.description.affiliationCtr Pesquisa Pecuaria Corte, Inst Zootecnia, Sertaozinho, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Agr & Vet, Dept Zootecnia, Jaboticabal, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent2050-2059
dc.identifierhttp://dx.doi.org/10.4238/vol9-4gmr850
dc.identifier.citationGenetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 9, n. 4, p. 2050-2059, 2010.
dc.identifier.doi10.4238/vol9-4gmr850
dc.identifier.fileWOS000284324400006.pdf
dc.identifier.issn1676-5680
dc.identifier.lattes7445254960858159
dc.identifier.lattes5866981114947883
dc.identifier.urihttp://hdl.handle.net/11449/4950
dc.identifier.wosWOS:000284324400006
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics and Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBeef cattleen
dc.subjectQTLen
dc.subjectSNPen
dc.subjectMarker assisted selectionen
dc.subjectZebuen
dc.titleEvaluation of TFAM and FABP4 gene polymorphisms in three lines of Nellore cattle selected for growthen
dc.typeResumo
dcterms.licensehttp://www.geneticsmr.com/node/2
dcterms.rightsHolderFunpec-editora
unesp.author.lattes7445254960858159
unesp.author.lattes5866981114947883
unesp.author.orcid0000-0002-2030-7590[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Zootecnia - FCAV