Effect of cocaine on periadolescent rats with or without early maternal separation

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dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.authorMarin, M.T. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:25:23Z
dc.date.available2014-05-20T13:25:23Z
dc.date.issued2002-11-01
dc.description.abstractCocaine-induced behavioral sensitization and weight loss were investigated in periadolescent Wistar rats kept with their mothers or subjected to repeated maternal separation. Litters allocated to the separation procedure were placed in a temperature-controlled (33ºC) chamber for 3 h per day from postnatal day 6 (P6) to P20. Non-handled rats were left undisturbed until weaning. Treatments were started on P30-31 and the test was performed on P36-37. Animals received injections of saline or cocaine (10 mg/kg, sc) twice daily for 5 days. on day 6 all animals received saline. on day 7 animals were challenged with 10 mg/kg cocaine and their locomotion was evaluated in activity cages. A third group received saline throughout the 7-day period. Body weights were recorded on P30-31 and P36-37. Two-way ANOVA on body weights showed a main effect of treatment group (F(1,35) = 10.446, P = 0.003; N = 10-12). Non-handled rats treated with cocaine for 5 days gained significantly less weight, while no significant effect was observed in maternally separated rats. Two-way ANOVA revealed a main effect of drug treatment on locomotor activity (F(2,32) = 15.209, P<0.001; N = 6-8), but not on rearing condition (F(1,32)<0.001, P = 0.998). Animals pretreated with cocaine showed a clear behavioral sensitization relative to the saline group. No difference in the magnitude of sensitization was found between separated and non-handled animals. Only the effect of cocaine on weight gain was significantly affected by repeated episodes of early maternal separation during the pre-weaning period.en
dc.description.affiliationUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas Laboratório de Farmacologia
dc.description.affiliationUnespUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas Laboratório de Farmacologia
dc.format.extent1367-1371
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2002001100015
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 11, p. 1367-1371, 2002.
dc.identifier.doi10.1590/S0100-879X2002001100015
dc.identifier.fileS0100-879X2002001100015.pdf
dc.identifier.issn0100-879X
dc.identifier.lattes2514762545280942
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.scieloS0100-879X2002001100015
dc.identifier.urihttp://hdl.handle.net/11449/8036
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectCocaineen
dc.subjectAdolescenceen
dc.subjectBehavioral sensitizationen
dc.subjectMaternal separationen
dc.subjectEarly stressen
dc.titleEffect of cocaine on periadolescent rats with or without early maternal separationen
dc.typeArtigo
unesp.author.lattes2514762545280942[1]
unesp.author.orcid0000-0002-1378-6327[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR