Quantitative HPLC analysis of sesquiterpene lactones and determination of chemotypes in Eremanthus seidelii MacLeish & Schumacher (Asteraceae)

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dc.contributor.authorSakamoto, Humberto T.
dc.contributor.authorGobbo-Neto, Leonardo
dc.contributor.authorCavalheiro, Alberto José [UNESP]
dc.contributor.authorLopes, Norberto P.
dc.contributor.authorLopes, João L. C.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:39Z
dc.date.available2014-05-27T11:21:39Z
dc.date.issued2005-11-01
dc.description.abstractEremanthus seidelii MacLeish & Schumacher has a restricted occurrence to the Brazilian cerrado surrounding the Furnas (MG) reservoir, in environments that have been seriously damaged by human activity. The present phytochemical investigation reveals that the sesquiterpene lactones (SL) 4β,5-dihydro-2′,3′-dihydroxy-15-desoxy-goyazensolide (1) and 4β,5-dihydro-1′,2′-epoxy-eremantholide-C (2) are the major secondary metabolites in E. seidelii leaves, and an HPLC method was developed for their quantitative analysis. HPLC analysis showed no significant seasonal variation in the concentrations of both SL. No qualitative differences were found in the SL patterns of all individuals sampled. However, there is a different SL quantitative pattern among the plants analyzed, pointing to the existence of three quantitative chemotypes of this species, with differences possibly originating from the activity of the enzymes that cyclize the goyazensolide type SL (1) to a eremantholide type SL (2). ©2005 Sociedade Brasileira de Química.en
dc.description.affiliationDepartamento de Química Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto Universidade de São Paulo, 14040-901 Ribeirão Preto - SP
dc.description.affiliationDepartamento de Física e Química Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, 14040-903 Ribeirão Preto - SP
dc.description.affiliationInstituto de Química Universidade Estadual Paulista, 14800-900 Araraquara - SP
dc.description.affiliationUnespInstituto de Química Universidade Estadual Paulista, 14800-900 Araraquara - SP
dc.format.extent1396-1401
dc.identifierhttp://dx.doi.org/10.1590/S0103-50532005000800016
dc.identifier.citationJournal of the Brazilian Chemical Society, v. 16, n. 6 B, p. 1396-1401, 2005.
dc.identifier.doi10.1590/S0103-50532005000800016
dc.identifier.file2-s2.0-30844450834.pdf
dc.identifier.issn0103-5053
dc.identifier.lattes2518006820764120
dc.identifier.scieloS0103-50532005000800016
dc.identifier.scopus2-s2.0-30844450834
dc.identifier.urihttp://hdl.handle.net/11449/68469
dc.identifier.wosWOS:000234078700016
dc.language.isoeng
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.relation.ispartofjcr1.444
dc.relation.ispartofsjr0,357
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectChemotypes
dc.subjectEremanthus seidelii
dc.subjectHPLC
dc.subjectPopulational variation
dc.subjectSesquiterpene lactones
dc.titleQuantitative HPLC analysis of sesquiterpene lactones and determination of chemotypes in Eremanthus seidelii MacLeish & Schumacher (Asteraceae)en
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jbchs/iaboutj.htm
unesp.author.lattes2518006820764120[3]
unesp.author.orcid0000-0001-8214-9957[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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