Lactational exposure to venlafaxine provokes late repercussions on reproductive parameters in male rat offspring

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dc.contributor.authorMoreira, Suyane da Silva [UNESP]
dc.contributor.authorManoel, Beatriz de Matos
dc.contributor.authorInacio, Joao Pedro Gaspar [UNESP]
dc.contributor.authorSouza, Carolina Gabrielli de [UNESP]
dc.contributor.authorReis, Ana Carolina Casali [UNESP]
dc.contributor.authorJorge, Barbara Campos [UNESP]
dc.contributor.authorAquino, Ariana Musa de [UNESP]
dc.contributor.authorScarano, Wellerson Rodrigo [UNESP]
dc.contributor.authorCardoso, Claudia Lima Andrea
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFed Univ Grande Dourados
dc.contributor.institutionUniversidade Estadual de Mato Grosso do Sul (UEMS)
dc.date.accessioned2022-11-30T13:46:47Z
dc.date.available2022-11-30T13:46:47Z
dc.date.issued2022-09-10
dc.description.abstractExposure to selective serotonin reuptake inhibitors can affect hormone-dependent processes, such as the brain sexual differentiation. Because the use of these antidepressants cause concern during lactation, we evaluated the possible effects of venlafaxine on lactational exposure and its late repercussions on reproductive parameters in male rats. Lactating rats were exposed to venlafaxine (3.85, 7.7, or 15.4 mg/kg/body weight; gavage), from lactational day 1 to 20. Venlafaxine and O-desmethylvenlafaxine residues were found in all milk samples of dams treated, demonstrating the lactational transfer of this antidepressant to the offspring. Although the maternal behavior was normal, the dams presented an increase in urea and uric acid levels in the groups treated with 7.7 and 15.4, respectively, as well as a spleen weight increased in the 3.85 and 15.4 groups. The male offspring showed a decrease in play behavior parameters in the intermediate dose group. Sperm analysis indicated a reduction in sperm motility in all treated groups. The androgen receptor expression in the hypothalamus was decreased in the highest dose group, although the sexual behavior had not been affected. In conclusion, venlafaxine was transferred through breast milk and promoted changes in play behavior, sperm quality, and hypothalamic androgen receptor (AR) content, which may indicate an incomplete masculinization of the brain of male offspring.en
dc.description.affiliationUniv Estadual Paulista, Inst Biosci Botucatu, Dept Struct & Funct Biol, UNESP, Dist Rubiao Jr S-N, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationFed Univ Grande Dourados, Sch Hlth Sci, UFGD, Dourados, MS, Brazil
dc.description.affiliationMato Grosso do Sul State Univ, UEMS, Dourados, MS, Brazil
dc.description.affiliationUniv Estadual Paulista Botucatu UNESP, Ctr Toxicol Assistance CEATOX, Inst Biosci Botucatu, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biosci Botucatu, Dept Struct & Funct Biol, UNESP, Dist Rubiao Jr S-N, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Botucatu UNESP, Ctr Toxicol Assistance CEATOX, Inst Biosci Botucatu, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2019/02902-8
dc.format.extent15
dc.identifierhttp://dx.doi.org/10.1002/jat.4389
dc.identifier.citationJournal Of Applied Toxicology. Hoboken: Wiley, 15 p., 2022.
dc.identifier.doi10.1002/jat.4389
dc.identifier.issn0260-437X
dc.identifier.urihttp://hdl.handle.net/11449/237855
dc.identifier.wosWOS:000852206700001
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Applied Toxicology
dc.sourceWeb of Science
dc.subjectBrain sexual differentiation
dc.subjectMaternal milk
dc.subjectPostpartum depression
dc.subjectSerotonin
dc.subjectSexual behavior
dc.titleLactational exposure to venlafaxine provokes late repercussions on reproductive parameters in male rat offspringen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell

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Botucatu - CEATOX - Centro de Assistência Toxicológica