Association between Adverse Maternal Clinical Outcomes and Imbalance of Cytokines and Angiogenic Factors in Preterm Preeclampsia

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dc.contributor.authorNunes, Priscila Rezeck [UNESP]
dc.contributor.authorRomao-Veiga, Mariana [UNESP]
dc.contributor.authorBorges, Vera Therezinha Medeiros [UNESP]
dc.contributor.authorMatias, Mariana Leticia [UNESP]
dc.contributor.authorRibeiro, Vanessa Rocha [UNESP]
dc.contributor.authorCosta, Roberto Antonio Araujo [UNESP]
dc.contributor.authorPeracoli, Maria Terezinha Serrao [UNESP]
dc.contributor.authorPeracoli, Jose Carlos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-05-01T09:47:32Z
dc.date.available2022-05-01T09:47:32Z
dc.date.issued2021-09-01
dc.description.abstractObjective Preeclampsia (PE) is a pregnancy-specific syndrome characterized by abnormal levels of cytokines and angiogenic factors, playing a role in the disease development. The present study evaluated whether immunological markers are associated with the gestational age and with the disease severity in preeclamptic women. Methods Ninety-five women who developed PE were stratified for gestational age as preterm PE (< 37 weeks) and term PE (≥ 37 weeks of gestation) and compared for disease severity as well as plasma concentration of angiogenic factors and cytokines. The concentrations of placental growth factor (PlGF), vascular endothelial growth factor (VEGF), Fms-like soluble tyrosine kinase (sFlt-1) and soluble endoglin (sEng), as well as the cytokines, tumor necrosis factor-α (TNF-α) and interleukin 10 (IL-10), were determined by enzyme-linked immunosorbent assay (ELISA). Results The comparison between preeclamptic groups showed a higher percentage of severe cases in preterm PE (82.1%) than in term PE (35.9%). Similarly, the concentrations of TNF-α, sFlt-1, and sEng, as well as TNF-α/IL-10 and sFlt-1/PlGF ratios were significantly higher in the preterm PE group. In contrast, concentrations of PlGF, VEGF, and IL-10 were significantly lower in women with preterm PE. Negative correlations between TNF-α and IL-10 (r = 0.5232) and between PlGF and sFlt1 (r = -0.4158) were detected in the preterm PE. Conclusion In pregnant women with preterm PE, there is an imbalance between immunological markers, with the predominance of anti-angiogenic factors and TNF-α, associated with adverse maternal clinical outcomes.en
dc.description.affiliationFaculdade de Medicina Universidade Estadual Paulista Julio de Mesquita Filho, SP
dc.description.affiliationUnespFaculdade de Medicina Universidade Estadual Paulista Julio de Mesquita Filho, SP
dc.format.extent669-675
dc.identifierhttp://dx.doi.org/10.1055/s-0041-1735157
dc.identifier.citationRevista Brasileira de Ginecologia e Obstetricia, v. 43, n. 9, p. 669-675, 2021.
dc.identifier.doi10.1055/s-0041-1735157
dc.identifier.issn0100-7203
dc.identifier.scopus2-s2.0-85118208262
dc.identifier.urihttp://hdl.handle.net/11449/233757
dc.language.isoeng
dc.relation.ispartofRevista Brasileira de Ginecologia e Obstetricia
dc.sourceScopus
dc.subjectangiogenic factors
dc.subjectclinical adverse outcomes
dc.subjectcytokines
dc.subjectpreterm preeclampsia
dc.subjectterm preeclampsia
dc.titleAssociation between Adverse Maternal Clinical Outcomes and Imbalance of Cytokines and Angiogenic Factors in Preterm Preeclampsiaen
dc.typeArtigo

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Artigos - Ginecologia e Obstetrícia - FMB
Artigos - Microbiologia e Imunologia - IBB