TRATAMENTO DA HIPERTENSAO ARTERIAL LEVE E MODERADA COM FOSINOPRIL. COMPARACAO DE EFEITOS ADVERSOS COM OUTROS ANTI-HIPERTENSIVOS

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dc.contributor.authorMartin, Luis Cuadrado [UNESP]
dc.contributor.authorVelasco-Cornejo, I. V. [UNESP]
dc.contributor.authorDa Silva Franco, R. J. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:17:57Z
dc.date.available2014-05-27T11:17:57Z
dc.date.issued1994-07-08
dc.description.abstractPurpose - To evaluate the adverse reactions of fosinopril with other antihypertensives used as monotherapy. Methods - Out-patients (n = 2,568) with diagnostic of mild to moderate hypertension, diastolic blood pressure (DBP) 95-115 mmHg, with no antihypertensive treatment for 15 days, were included to treatment initially with fosinopril (F) 10mg, once daily, for six weeks. After this period, patients with DBP >95mmHg had the dosage, once daily, increased to 20 mg, while the others were maintained with the same dosage for six more weeks. Adverse reactions of 822 patients treated as monotherapy were grouped as absent, musculoskeletal, cardiovascular, cough, gastrointestinal, neurological, genital-urinary dysfunctions and dermatological and compared with 1,568 with F. Monotherapy consist in α-methyldopa (100 patients); β-blocker (129); calcium blocker (106); diuretic (394); and another ACE inhibitors (93). Results - At the end of the period without treatment, the blood pressure (BP), 165 ± 16/105 ± 7 mmHg decreased significantly at 6(th) week to 144 ± 15/91 ± 9 mmHg (p < 0.05 vs week 0) with further lowering to 139 ± 13/86 ± 7 mmHg till the end of 12(th) week. BP response (DBP ≤90 mmHg) was obtained in 89% of the patients with F. Absence of adverse reactions were ≥70% in patients with F compared to other drugs. Conclusion - Fosinopril has demonstrated therapeutic efficacy and less adverse reactions compared to antihypertensives used previously as monotherapy.en
dc.description.affiliationDepto de Clinica Medica Faculdade de Medicina UNESP, 18618-000 - Botucatu, SP
dc.description.affiliationUnespDepto de Clinica Medica Faculdade de Medicina UNESP, 18618-000 - Botucatu, SP
dc.format.extent369-374
dc.identifierhttp://www.arquivosonline.com.br/pesquisartigos/Pdfs/1994/V62N5/62050014.pdf
dc.identifier.citationArquivos Brasileiros de Cardiologia, v. 62, n. 5, p. 369-374, 1994.
dc.identifier.file2-s2.0-0028214378.pdf
dc.identifier.issn0066-782X
dc.identifier.lattes7095933557855151
dc.identifier.lattes4923203168446615
dc.identifier.scopus2-s2.0-0028214378
dc.identifier.urihttp://hdl.handle.net/11449/64491
dc.language.isopor
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.relation.ispartofjcr1.318
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectangiotensin converting enzyme inhibitor
dc.subjectfosinopril
dc.subjecthypertension
dc.subjectbeta adrenergic receptor blocking agent
dc.subjectcalcium antagonist
dc.subjectdipeptidyl carboxypeptidase inhibitor
dc.subjectdiuretic agent
dc.subjectmethyldopa
dc.subjectantihypertensive agent
dc.subjectadult
dc.subjectaged
dc.subjectblood pressure
dc.subjectcardiotoxicity
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectcoughing
dc.subjectdrug efficacy
dc.subjectfemale
dc.subjectgastrointestinal symptom
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmusculoskeletal injury
dc.subjectneurotoxicity
dc.subjectoral drug administration
dc.subjectskin toxicity
dc.subjectadolescent
dc.subjectambulatory care
dc.subjectcomparative study
dc.subjectmulticenter study
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAmbulatory Care
dc.subjectAntihypertensive Agents
dc.subjectComparative Study
dc.subjectEnglish Abstract
dc.subjectFemale
dc.subjectFosinopril
dc.subjectHuman
dc.subjectHypertension
dc.subjectMale
dc.subjectMiddle Age
dc.titleTRATAMENTO DA HIPERTENSAO ARTERIAL LEVE E MODERADA COM FOSINOPRIL. COMPARACAO DE EFEITOS ADVERSOS COM OUTROS ANTI-HIPERTENSIVOSpt
dc.title.alternativeTreatment of mild-to-moderate hypertension with fosinopril. Adverse reactions compared with other antihypertensivesen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/abc/paboutj.htm#03
unesp.author.lattes7095933557855151
unesp.author.lattes4923203168446615
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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