Molecular modeling and small angle X-ray scattering studies of Hoplosternum littorale cathodic haemoglobin

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dc.contributor.authorPeres, P.
dc.contributor.authorLombardi, F. R.
dc.contributor.authordos Santos, G. C.
dc.contributor.authorOlivieri, JR
dc.contributor.authorCanduri, F.
dc.contributor.authorBonilla-Rodriguez, G. O.
dc.contributor.authorde Azevedo, W. F.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Butantan
dc.date.accessioned2014-05-20T15:21:36Z
dc.date.available2014-05-20T15:21:36Z
dc.date.issued2004-12-10
dc.description.abstractConsiderable interest is currently focused on fish haemoglobins in order to identify the structural basis for their diversity of functional behavior. Hoplosternum littorale is a catfish that presents bimodal gill (water)/gut (air) -breathing, which allows this species to survive in waters with low oxygen content. The hemolysate of this fish showed the presence of two main haemoglobins, cathodic and anodic. This work describes structural features analyzed here by integration of molecular modeling with small angle X-ray scattering. Here is described a molecular model for the cathodic haemoglobin in the unliganded and liganded states. The models were determined by molecular modeling based on the high-resolution crystal structure of fish haemoglobins. The structural models for both forms of H. littorale haemoglobin were compared to human haemoglobin. (C) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP, Dept Fis, Programa Pos Grad Biofis Mol, BR-15054000 Sao Jose Dos Campos, Brazil
dc.description.affiliationInst butantan, Ctr Appl Technol, BR-05503900 São Paulo, Brazil
dc.description.affiliationUNESP, Dept Quim & Ciências Ambientais, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Fis, Programa Pos Grad Biofis Mol, BR-15054000 Sao Jose Dos Campos, Brazil
dc.description.affiliationUnespUNESP, Dept Quim & Ciências Ambientais, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.format.extent487-493
dc.identifierhttp://dx.doi.org/10.1016/j.bbrc.2004.10.061
dc.identifier.citationBiochemical and Biophysical Research Communications. San Diego: Academic Press Inc. Elsevier B.V., v. 325, n. 2, p. 487-493, 2004.
dc.identifier.doi10.1016/j.bbrc.2004.10.061
dc.identifier.issn0006-291X
dc.identifier.lattes2406867656111498
dc.identifier.urihttp://hdl.handle.net/11449/32722
dc.identifier.wosWOS:000225279600017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.relation.ispartofjcr2.559
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcatfishpt
dc.subjectcathodic haemoglobinpt
dc.subjectHoplosternum littoralept
dc.subjectmolecular modelingpt
dc.subjectSAXSpt
dc.subjectbioinformaticspt
dc.subjectStructurept
dc.titleMolecular modeling and small angle X-ray scattering studies of Hoplosternum littorale cathodic haemoglobinen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2406867656111498
unesp.author.orcid0000-0001-9902-2557[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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Artigos - Química e Ciências Ambientais - IBILCE