Graves’ ophthalmopathy: Low-dose dexamethasone reduces retinoic acid receptor-alpha gene expression in orbital fibroblasts

Página do item simplificado
dc.contributor.authorCury, Sarah Santiloni [UNESP]
dc.contributor.authorOliveira, Miriane [UNESP]
dc.contributor.authorSíbio, Maria Teresa [UNESP]
dc.contributor.authorClara, Sueli [UNESP]
dc.contributor.authorLuvizotto, Renata De Azevedo Melo [UNESP]
dc.contributor.authorConde, Sandro
dc.contributor.authorJorge, Edson Nacib [UNESP]
dc.contributor.authorNunes, Vania Dos Santos [UNESP]
dc.contributor.authorNogueira, Célia Regina [UNESP]
dc.contributor.authorMazeto, Gláucia Maria Ferreira da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCiência e Tecnologia do Estado de São Paulo (IFSP)
dc.date.accessioned2018-12-11T17:21:56Z
dc.date.available2018-12-11T17:21:56Z
dc.date.issued2018-06-01
dc.description.abstractObjective: Graves’ ophthalmopathy (GO) is an autoimmune disease that leads to ocular proptosis caused by fat accumulation and inflammation, and the main treatment is corticosteroid therapy. Retinoid acid receptor-alpha (RARα) seems to be associated with inflammation and adipocyte differentiation. This study aimed to assess the effect of glucocorticoid treatment on orbital fibroblasts of GO patient treated or not with different glucocorticoid doses. Materials and methods: Orbital fibroblasts collected during orbital decompression of a female patient with moderately severe/severe GO were cultivated and treated with 10 nM and 100 nM dexamethasone (Dex). RARα gene expression in the treated and untreated cells was then compared. Results: Fibroblast RARα expression was not affected by 100 nM Dex. On the other hand, RARα expression was 24% lower in cells treated with 10 nM Dex (p < 0.05). Conclusions: Orbital fibroblasts from a GO patient expressed the RARα gene, which was unaffected by higher, but decreased with lower doses of glucocorticoid.en
dc.description.affiliationDivisão de Endocrinologia Departamento de Medicina Interna Faculdade de Medicina de Botucatu Universidade Estadual de São Paulo (Unesp)
dc.description.affiliationInstituto Federal de Educação Ciência e Tecnologia do Estado de São Paulo (IFSP)
dc.description.affiliationDepartamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeça e Pescoço Faculdade de Medicina de Botucatu Universidade Estadual de São Paulo (Unesp)
dc.description.affiliationUnespDivisão de Endocrinologia Departamento de Medicina Interna Faculdade de Medicina de Botucatu Universidade Estadual de São Paulo (Unesp)
dc.description.affiliationUnespDepartamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeça e Pescoço Faculdade de Medicina de Botucatu Universidade Estadual de São Paulo (Unesp)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: #:03/03651-0
dc.description.sponsorshipIdFAPESP: 2011/18464-8
dc.format.extent366-369
dc.identifierhttp://dx.doi.org/10.20945/2359-3997000000044
dc.identifier.citationArchives of Endocrinology and Metabolism, v. 62, n. 3, p. 366-369, 2018.
dc.identifier.doi10.20945/2359-3997000000044
dc.identifier.fileS2359-39972018000300366.pdf
dc.identifier.issn2359-4292
dc.identifier.issn2359-3997
dc.identifier.lattes6692227903300380
dc.identifier.orcid0000-0003-3121-440X
dc.identifier.scieloS2359-39972018000300366
dc.identifier.scopus2-s2.0-85050760688
dc.identifier.urihttp://hdl.handle.net/11449/176653
dc.language.isoeng
dc.relation.ispartofArchives of Endocrinology and Metabolism
dc.relation.ispartofsjr0,505
dc.relation.ispartofsjr0,505
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectGene expression
dc.subjectGraves ophthalmopathy
dc.subjectReceptors
dc.subjectRetinoic acid
dc.titleGraves’ ophthalmopathy: Low-dose dexamethasone reduces retinoic acid receptor-alpha gene expression in orbital fibroblastsen
dc.typeArtigo
unesp.author.lattes6692227903300380[7]
unesp.author.lattes7607038776901890[9]
unesp.author.orcid0000-0002-4014-0660[9]

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S2359-39972018000300366.pdf
Tamanho:
121.03 KB
Formato:
Adobe Portable Document Format
Baixar

Coleções

Artigos - Clínica Médica - FMB
Artigos - Oftalmo/Otorrino e CCP - FMB