Sporothrix pathogenic clade: Molecular analysis of animal and human clinical isolates

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dc.contributor.authorRibeiro-Marques, Mariela Domiciano
dc.contributor.authorMaschio-Lima, Taiza [UNESP]
dc.contributor.authorLemes, Thiago Henrique [UNESP]
dc.contributor.authorSiqueira, João Paulo Zen
dc.contributor.authorBrizzotti-Mazuchi, Natália Seron
dc.contributor.authorCaetano, Maicon Henrique [UNESP]
dc.contributor.authorAlmeida, Bianca Gottardo
dc.contributor.authorMozaner, Leticia Queiroz [UNESP]
dc.contributor.authorMonteiro, Ruan Campos
dc.contributor.authorCamargo, Zoilo Pires
dc.contributor.authorRodrigues, Anderson Messias
dc.contributor.authorGottardo De Almeida, Margarete Teresa [UNESP]
dc.contributor.institutionSão José Do Rio Preto School of Medicine (FAMERP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-07-29T14:00:16Z
dc.date.available2023-07-29T14:00:16Z
dc.date.issued2023-01-01
dc.description.abstractSporotrichosis is a subcutaneous mycosis that affects animals and humans. Varying in severity, occurrences range from local lesions to systemic involvement. It is caused by thermodimorphic and saprobic fungi from the Sporothrix pathogenic clade. This study aimed to identify the species and the sexual idiomorph distribution patterns responsible for diagnosed cases of sporotrichosis in São José do Rio Preto, Brazil. We included 188 isolates of Sporothrix sp. from feline lesions and 27 of human origin, which underwent molecular identification and genotyping for mating-type MAT1-1 and MAT1-2. The results showed that Sporothrix brasiliensis is the prevalent species in feline sporotrichosis outbreaks with the overwhelming presence of a single mating-type, MAT1-2 (P <.0001), suggesting a prevalently clonal form of spread. Morphological analyses did not discriminate among cryptic species in the genus Sporothrix, and molecular identification was essential for the correct identification of the species responsible for the observed cases of sporotrichosis. Distribution analyses of MAT1-2 isolates support the hypothesis of unidirectional migration from the current epidemics in São Paulo and Rio de Janeiro to the municipality of São José do Rio Preto.en
dc.description.affiliationDepartment of Dermatological Infectious and Parasitic Diseases São José Do Rio Preto School of Medicine (FAMERP), São Paulo
dc.description.affiliationInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), São Paulo
dc.description.affiliationDepartment of Microbiology Immunology and Parasitology Laboratory of Emerging Fungal Pathogens Federal University of São Paulo, São Paulo
dc.description.affiliationUnespInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), São Paulo
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCAPES: CAPES
dc.description.sponsorshipIdCNPq: CNPq
dc.description.sponsorshipIdFAPESP: FAPESP
dc.identifierhttp://dx.doi.org/10.1093/mmy/myac096
dc.identifier.citationMedical Mycology, v. 61, n. 1, 2023.
dc.identifier.doi10.1093/mmy/myac096
dc.identifier.issn1460-2709
dc.identifier.issn1369-3786
dc.identifier.scopus2-s2.0-85145022687
dc.identifier.urihttp://hdl.handle.net/11449/249023
dc.language.isoeng
dc.relation.ispartofMedical Mycology
dc.sourceScopus
dc.subjectMAT1-2
dc.subjectmating-type
dc.subjectspecies-specific PCR
dc.subjectSporothrix brasiliensis
dc.subjectsporotrichosis
dc.titleSporothrix pathogenic clade: Molecular analysis of animal and human clinical isolatesen
dc.typeArtigo
unesp.author.orcid0000-0002-7381-4545[1]
unesp.author.orcid0000-0002-7906-1337[3]
unesp.author.orcid0000-0002-5807-9204[4]

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Artigos - Dermatologia e Radioterapia - FMB
Artigos - Parasitologia - IBB