Peripheral spectrum neurological disorder after arbovirus infection is associated with HLA-F variants among Northeastern Brazilians

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dc.contributor.authorSonon, Paulin
dc.contributor.authorCollares, Cristhianna V.A.
dc.contributor.authorFerreira, Maria Lúcia Brito
dc.contributor.authorAlmeida, Renata Santos
dc.contributor.authorSadissou, Ibrahim
dc.contributor.authorCordeiro, Marli Tenório
dc.contributor.authorde Fátima Militão de Albuquerque, Maria
dc.contributor.authorCastelli, Erick C. [UNESP]
dc.contributor.authorLucena-Silva, Norma
dc.contributor.authorDonadi, Eduardo A.
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHospital da Restauração Gov. Paulo Guerra
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T10:58:51Z
dc.date.available2021-06-25T10:58:51Z
dc.date.issued2021-08-01
dc.description.abstractIntroduction: Non-classical class I human leukocyte antigens (HLA) molecules are known to modulate the function of cytotoxic cells (NK and T CD8+) during viral infection by interacting with inhibitory/activating receptors. However, little is known about the HLA-E/-F genetic variability on arbovirus infections. Methods: We evaluated by massive parallel sequencing the full HLA-E/-F genetic diversity among patients infected during the arbovirus (ZIKV, DENV, and CHIKV) outbreak leading to a broad range of neurological complications in the Brazilian State of Pernambuco. In parallel, healthy blood donors from the same area were also studied. Plink and R software were used for genetic association study. To limit the false-positive results and enhance the reliability of the results, we adopted P-values <0.01 as significant levels. Results: Compared to controls, the HLA-F alleles: −1610 C (rs17875375), +1383 G (rs17178385), and +3537 A (rs17875384), all in complete linkage disequilibrium with each other (r2 = 1), were overrepresented in patients presenting peripheral spectrum disorders (PSD). The HLA-F*Distal-D haplotype that harbored the −1610 C allele exhibited a trend increase in PSD group. No associations were found for HLA-E. Conclusions: Our findings showed that the HLA-F genetic background seems to be more important than HLA-E on the susceptibility to PSD complications.en
dc.description.affiliationImmunogenetic Laboratory Immunology Department Aggeu Magalhães Institute Oswaldo Cruz Foundation, Av. Moraes rego, s/n, Campus da UFPE, Cidade Universitária
dc.description.affiliationRibeirão Preto Medical School University of São Paulo, AV Bandeirantes, 3900, HC, Vila Monte Alegre
dc.description.affiliationHospital da Restauração Gov. Paulo Guerra, Av. Gov. Agamenon Magalhães, s/n, Derby
dc.description.affiliationVirology Department Aggeu Magalhães Institute Oswaldo Cruz Foundation, Av. Moraes rego, s/n, Campus da UFPE, Cidade Universitária
dc.description.affiliationPublic Health Department Aggeu Magalhães Institute Oswaldo Cruz Foundation, Av. Moraes rego, s/n, Campus da UFPE, Cidade Universitária
dc.description.affiliationSão Paulo State University (UNESP) School of Medicine Molecular Genetics and Bioinformatics Laboratory Prof. Dr. Walter Maurício Correa, s/n Unesp, Campus de Botucatu
dc.description.affiliationSão Paulo State University (UNESP) Department of Pathology School of Medicine
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Medicine Molecular Genetics and Bioinformatics Laboratory Prof. Dr. Walter Maurício Correa, s/n Unesp, Campus de Botucatu
dc.description.affiliationUnespSão Paulo State University (UNESP) Department of Pathology School of Medicine
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação Oswaldo Cruz
dc.description.sponsorshipIdCNPq: 302060/2019-7
dc.description.sponsorshipIdCNPq: 310364/2015-9
dc.description.sponsorshipIdCNPq: 310892/2019-8
dc.description.sponsorshipIdCNPq: 440760/2016-0
dc.description.sponsorshipIdCAPES: 88881.130769/2016-01
dc.description.sponsorshipIdFundação Oswaldo Cruz: INOVA FIOCRUZ/02/2019 PDJ
dc.identifierhttp://dx.doi.org/10.1016/j.meegid.2021.104855
dc.identifier.citationInfection, Genetics and Evolution, v. 92.
dc.identifier.doi10.1016/j.meegid.2021.104855
dc.identifier.issn1567-7257
dc.identifier.issn1567-1348
dc.identifier.scopus2-s2.0-85104908124
dc.identifier.urihttp://hdl.handle.net/11449/207658
dc.language.isoeng
dc.relation.ispartofInfection, Genetics and Evolution
dc.sourceScopus
dc.subjectArbovirus
dc.subjectESD
dc.subjectHLA-E
dc.subjectHLA-F
dc.subjectPernambuco
dc.subjectPSD
dc.titlePeripheral spectrum neurological disorder after arbovirus infection is associated with HLA-F variants among Northeastern Braziliansen
dc.typeArtigo

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