Annona sp: Plants with multiple applications as alternative medicine - a review

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dc.contributor.authorBarbalho, Sandra M.
dc.contributor.authorde Alvares Goulart, Ricardo
dc.contributor.authorFarinazzi-Machado, Flávia Maria Vasques
dc.contributor.authorde Souza, Maricelma da Silva Soares
dc.contributor.authordos Santos Bueno, Patrícia Cincotto
dc.contributor.authorGuiguer, Élen Landgraf
dc.contributor.authorAraújo, Adriano Cressoni [UNESP]
dc.contributor.authorGroppo, Milton
dc.contributor.institutionUniversidade de Marília (UNIMAR)
dc.contributor.institutionFaculdade de Tecnologia do Estado de São Paulo (FATEC)
dc.contributor.institutionFaculdade de Medicina de Marília (FAMEMA)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:27:06Z
dc.date.available2014-05-27T11:27:06Z
dc.date.issued2012-10-08
dc.description.abstractAnnona species have been used as a natural remedy for a variety of illnesses with antiparasitic, antispasmodic, antidiarrheal, antiulcer, sedative, analgesic, hypotensive, and vermifugal effects. These properties are due to the presence of a number of bioactive compounds on the leaves, fruit, seeds, and stem. The aim of this review is to show the main species of Annona, their medicinal properties and the chemical constituents that may be related to these effects. In the leaves it is possible to find acetogenins, annopentocins A, B, and C, cis- and trans-annomuricin-D-ones, goniothalamicin, arianacin, and javoricin, related to anticancer properties. Quercetin-3-O-glucoside, also found in the leaves mediates antidiabetic and antioxidative effects. In the fruit are found annonaine, nornuciferine and asimilobine, associated to antidepressive effects. In the seeds are found muricatetrocin A and muricatetrocin B, longifolicin, corossolin, corossolone, uvarigrandin A, bullatacin, squamotatin. These acetogenins are associated with anticancer effects. Cyclosquamosin B, quercetin, and cyclosquamosin from the seeds have respectively vasorelaxant, antithyroidal and, antiinflammatory activity. In the stem parts there are several components as N-trans-feruloyltyramine, N-p-coumaroyltyramine, and N-trans-caffeoyltyramine, lignans, syringaresinol, syringaldehyde, beta-sitosterol and beta-sitosterol-beta-D-glucoside which exhibit antiplatelet aggregation activity. Copaene, patchoulane, 1H-cycloprop (e) azulene and kaur-16-en-19-oic acid found in the barks exhibit significant central as well as peripheral analgesic and antiinflammatory activities. The properties of the biological compounds in Annona species support information that may provide validation for its medicinal uses, but further studies should be performed to establish ideal and safe doses of consumption to ensure the effectiveness of the benefits. © 2012 Bentham Science Publishers.en
dc.description.affiliationDepartment of Biochemistry and Pharmacology, School of Medicine University of Marília, Av. Higino Muzzi Filho 1001, Marília 15525-902, SP
dc.description.affiliationDepartment of Biochemistry and Nutrition Faculty of Food Technology of Marília (FATEC), Av. Castro Alves, 62, Marília 17506-000, SP
dc.description.affiliationSchool of Medicine - FAMEMA, Av. Monte Carmelo, 800 - Marília - SP CEP 17519-030, SP
dc.description.affiliationRibeirão Preto School of Philosophy Sciences and Literature University of São Paulo, Avenida Bandeirantes, 3900, Ribeirão Preto 14040-030, SP
dc.description.affiliationLaboratory of Phytomedicine, Dept. Pharmacology Institute of Biosciences UNESP - Botocatu, SP. 18618-970 São Paulo
dc.description.affiliationUnespLaboratory of Phytomedicine, Dept. Pharmacology Institute of Biosciences UNESP - Botocatu, SP. 18618-970 São Paulo
dc.format.extent277-286
dc.identifierhttp://dx.doi.org/10.2174/157340712802762500
dc.identifier.citationCurrent Bioactive Compounds, v. 8, n. 3, p. 277-286, 2012.
dc.identifier.doi10.2174/157340712802762500
dc.identifier.issn1573-4072
dc.identifier.issn1875-6646
dc.identifier.scopus2-s2.0-84866983610
dc.identifier.urihttp://hdl.handle.net/11449/73657
dc.language.isoeng
dc.relation.ispartofCurrent Bioactive Compounds
dc.relation.ispartofsjr0,183
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAnnona crassilfora
dc.subjectAnnona montana
dc.subjectAnnona muricata
dc.subjectAnnona reticulata
dc.subjectAnnona squamosa
dc.subjectAntidiabetic
dc.subjectAntioxidative
dc.subjectacetogenin
dc.subjectannopentocin A
dc.subjectannopentocin B
dc.subjectannopentocin C
dc.subjectanonaine
dc.subjectantidepressant agent
dc.subjectantidiabetic agent
dc.subjectantiinflammatory agent
dc.subjectantineoplastic agent
dc.subjectantioxidant
dc.subjectarianacin
dc.subjectasimilobine
dc.subjectbullatacin
dc.subjectcorossolin
dc.subjectcorossolone
dc.subjectcyclosquamosin
dc.subjectcyclosquamosin B
dc.subjectgoniothalamicin
dc.subjectjavoricin
dc.subjectlongifolicin
dc.subjectmuricatetrocin A
dc.subjectmuricatetrocin B
dc.subjectnornuciferine
dc.subjectplant medicinal product
dc.subjectquercetin
dc.subjectquercetin 3 methyl ether
dc.subjectsquamotatin
dc.subjectunclassified drug
dc.subjectunindexed drug
dc.subjectuvarigrandin A
dc.subjectvasodilator agent
dc.subjectAnnona
dc.subjectAnnona cherimola
dc.subjectAnnona coriacea
dc.subjectAnnona crassiflora
dc.subjectAnnona cuneata
dc.subjectantidiabetic activity
dc.subjectantiinflammatory activity
dc.subjectantineoplastic activity
dc.subjectbark
dc.subjectfruit
dc.subjectnonhuman
dc.subjectplant leaf
dc.subjectplant seed
dc.subjectplant stem
dc.subjectpriority journal
dc.subjectreview
dc.titleAnnona sp: Plants with multiple applications as alternative medicine - a reviewen
dc.typeResenha
dcterms.licensehttp://eurekaselect.com/209
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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