Light-Emitting Diode Therapy in Chemotherapy-Induced Mucositis

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dc.contributor.authorSacono, Nancy T. [UNESP]
dc.contributor.authorCosta, Carlos A. S. [UNESP]
dc.contributor.authorBagnato, Vanderlei S.
dc.contributor.authorAbreu e Lima, Fabio Cesar Braga de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2013-09-30T18:31:17Z
dc.date.accessioned2014-05-20T13:44:51Z
dc.date.available2013-09-30T18:31:17Z
dc.date.available2014-05-20T13:44:51Z
dc.date.issued2008-11-01
dc.description.abstractBackground and Objective: Mucositis is the most common oral complication of cancer chemotherapy, which causes pain on mastication and swallowing, impairs patients' ability to eat and take oral drugs and may determine interruption of the treatment. The aim of this study was to evaluate the effect of light-emitting diode (LED) therapy on chemotherapy-induced mucositis in hamsters.Study Design/Materials and Methods: Animals of both experimental (Group 1; n = 32) and positive control (Group II; n = 32) groups received intraperitoneal injections of 5-fluorouracil on days 0 and 2. All animals had their right and left cheek pouch irritated by superficial scratching on days 3 and 4. In Group I, LED irradiation (630 nm +/- 10 nm, 160 mW, 12 J/cm(2)) was applied during 37.5 seconds at days 3, 4, 6, 8, 10, 12, and 14. In Group II, mucositis was induced, but LED therapy was not performed. The oral mucosa was photographed from day 4 to 14 at 2-day intervals. Photographs were randomly scored according to the severity of induced mucositis (0 to 5). In the negative control group (Group III; n = 6), no mucositis was induced. Biopsies of the cheek pouches of 8 animals (Group I and Group II) were surgically obtained on days 5, 9, 13 and 15 and processed for histological examination.Results: The statistical analysis showed significant differences between irradiated and non-irradiated groups (P < 0.05). However, muscular degeneration was observed in 18% of the samples of Group I.Conclusion: It may be concluded that the LED therapy protocol established for this in vivo study was effective in reducing the severity of oral mucositis, although the oral lesions were not completely prevented. Lasers Surg. Med. 40:625-633, 2008. (c) 2008Wiley-Liss, Inc.en
dc.description.affiliationSão Paulo State Univ, Araraquara Sch Dent, Dept Orthodont & Pediat Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Araraquara Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Phys Inst São Carlos, BR-13560970 São Carlos, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Araraquara Sch Dent, Dept Orthodont & Pediat Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Araraquara Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 476137/2006-3
dc.description.sponsorshipIdCNPq: 301029/2007-5
dc.description.sponsorshipIdFAPESP: 07/50646-3
dc.format.extent625-633
dc.identifierhttp://dx.doi.org/10.1002/lsm.20677
dc.identifier.citationLasers In Surgery and Medicine. Hoboken: Wiley-liss, v. 40, n. 9, p. 625-633, 2008.
dc.identifier.doi10.1002/lsm.20677
dc.identifier.issn0196-8092
dc.identifier.lattes7786618999715779
dc.identifier.orcid0000-0002-1165-2181
dc.identifier.urihttp://hdl.handle.net/11449/15735
dc.identifier.wosWOS:000260922200005
dc.language.isoeng
dc.publisherWiley-liss
dc.relation.ispartofLasers In Surgery and Medicine
dc.relation.ispartofjcr2.726
dc.relation.ispartofsjr0,926
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdrug therapyen
dc.subjectfluorouracilen
dc.subjecthamstersen
dc.subjectneoplasmsen
dc.subjectoral mucosaen
dc.subjectphototherapyen
dc.titleLight-Emitting Diode Therapy in Chemotherapy-Induced Mucositisen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-liss
unesp.author.lattes7786618999715779[4]
unesp.author.lattes4517484241515548[2]
unesp.author.orcid0000-0002-7455-6867[2]
unesp.author.orcid0000-0002-1165-2181[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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