A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometry

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dc.contributor.authorTótoli, Eliane Gandolpho [UNESP]
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:27:47Z
dc.date.available2018-12-11T17:27:47Z
dc.date.issued2015-10-01
dc.description.abstractDaptomycin is the first approved drug from a new class of antimicrobials, the cyclic lipopeptides, and is a very important antimicrobial agent in current clinical practice. Currently, there are no “green” analytical methods described in the literature to analyze the typical pharmaceutical dosage form of daptomycin. Thus, the aim of this work was to validate an environment-friendly spectrophotometric method in the UV region, for the analysis of daptomycin as a lyophilized powder. Water was used as diluent and the analyses were carried out on a spectrophotometer at 221 nm. The method met all validation requirements of the ICH guidelines, over a concentration range of 6-21 μg mL-1. A Student’s t-test demonstrated that the proposed method was comparable to an HPLC method previously validated. Thus, the validated spectrophotometric method could quantify daptomycin in a powder form for injectable solutions, while being an economical, rapid, and “green” alternative for routine analysis in quality control.en
dc.description.affiliationSchool of Pharmaceutical Sciences Universidade Estadual Paulista “Júlio de Mesquita Filho” UNESP
dc.description.affiliationUnespSchool of Pharmaceutical Sciences Universidade Estadual Paulista “Júlio de Mesquita Filho” UNESP
dc.format.extent811-821
dc.identifierhttp://dx.doi.org/10.1590/S1984-82502015000400007
dc.identifier.citationBrazilian Journal of Pharmaceutical Sciences, v. 51, n. 4, p. 811-821, 2015.
dc.identifier.doi10.1590/S1984-82502015000400007
dc.identifier.fileS1984-82502015000400811.pdf
dc.identifier.issn2175-9790
dc.identifier.issn1984-8250
dc.identifier.scieloS1984-82502015000400811
dc.identifier.scopus2-s2.0-84962757590
dc.identifier.urihttp://hdl.handle.net/11449/177940
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.relation.ispartofsjr0,214
dc.relation.ispartofsjr0,214
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntimicrobials/quality control
dc.subjectDaptomycin/determination
dc.subjectSpectrophotometry/green analytical method
dc.subjectSpectrophotometry/UV region/ quantitative analysis
dc.titleA green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometryen
dc.typeArtigo

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