Circulating levels of tissue inhibitor of metalloproteinase 3, a protein with inhibitory effects on angiogenesis, are increased in pre-eclampsia

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dc.contributor.authorPalei, Ana C.
dc.contributor.authorCruz, Juliana de O.
dc.contributor.authorChaguri, João Leandro [UNESP]
dc.contributor.authorPeraçoli, José Carlos [UNESP]
dc.contributor.authorRomão-Veiga, Mariana [UNESP]
dc.contributor.authorRibeiro-Vasques, Vanessa R. [UNESP]
dc.contributor.authorCavalli, Ricardo C.
dc.contributor.authorNunes, Priscila R. [UNESP]
dc.contributor.authorLuizon, Marcelo R.
dc.contributor.authorSandrim, Valéria C. [UNESP]
dc.contributor.institutionUniversity of Mississippi Medical Center
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-07-29T13:31:18Z
dc.date.available2023-07-29T13:31:18Z
dc.date.issued2023-05-01
dc.description.abstractObjective: To assess and compare circulating tissue inhibitor of metalloproteinase 3 (TIMP-3) concentrations between women with pre-eclampsia and healthy pregnant women. We also aimed to determine the relationships between circulating TIMP-3 and matrix metalloproteinase 2 (MMP-2), MMP-9, TIMP-1, and TIMP-2 concentrations in pre-eclampsia. Methods: A primary case–control study included patients with pre-eclampsia (n = 219) and gestational hypertension (n = 118), healthy pregnant women (n = 214), and non-pregnant women (n = 66), and a replication case–control study included patients with pre-eclampsia (n = 177) and healthy pregnant women (n = 124), all from southeastern Brazil. Plasma TIMP-3, MMP-2, MMP-9, TIMP-1, and TIMP-2 concentrations were assessed using commercially available enzyme-linked immunosorbent assay kits, and the relationships between them were analyzed using Spearman's correlation. Results: In our primary study, patients with pre-eclampsia and gestational hypertension exhibited increased TIMP-3 concentrations compared with healthy pregnant women (both P < 0.0001) and non-pregnant women (both P < 0.001). These findings were confirmed in the replication study, showing elevated TIMP-3 concentrations in women with pre-eclampsia versus healthy pregnant women (P < 0.001). We found no difference in TIMP-3 concentrations between early-onset and late-onset pre-eclampsia. Moreover, TIMP-3 concentrations were significantly correlated with plasma concentrations of TIMP-1 (r = 0.2333; P = 0.0086) and MMP-2 (r = 0.2159; P = 0.0156) in pre-eclampsia. Conclusions: Circulating TIMP-3 concentration is increased in women with pre-eclampsia compared with healthy pregnant women, and it is positively correlated with plasma MMP-2 and TIMP-1 concentrations in pre-eclampsia.en
dc.description.affiliationDepartment of Surgery School of Medicine University of Mississippi Medical Center
dc.description.affiliationCardiovascular-Renal Research Center University of Mississippi Medical Center
dc.description.affiliationDepartment of Genetics Ecology and Evolution Institute of Biological Sciences Federal University of Minas Gerais, Minas Gerais
dc.description.affiliationDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Sao Paulo State University (Unesp), Sao Paulo
dc.description.affiliationCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Sao Paulo State University (Unesp), Sao Paulo
dc.description.affiliationDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University (Unesp), Sao Paulo
dc.description.affiliationDepartment of Chemistry and Biological Sciences Institute of Biosciences of Botucatu Sao Paulo State University (Unesp), Sao Paulo
dc.description.affiliationDepartment of Gynecology and Obstetrics Faculty of Medicine of Ribeirao Preto University of Sao Paulo (USP), Sao Paulo
dc.description.affiliationUnespDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Sao Paulo State University (Unesp), Sao Paulo
dc.description.affiliationUnespCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Sao Paulo State University (Unesp), Sao Paulo
dc.description.affiliationUnespDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University (Unesp), Sao Paulo
dc.description.affiliationUnespDepartment of Chemistry and Biological Sciences Institute of Biosciences of Botucatu Sao Paulo State University (Unesp), Sao Paulo
dc.description.sponsorshipFundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipIdNational Institutes of Health: R01HL148191
dc.description.sponsorshipIdNational Institutes of Health: U54GM115428
dc.format.extent544-551
dc.identifierhttp://dx.doi.org/10.1002/ijgo.14552
dc.identifier.citationInternational Journal of Gynecology and Obstetrics, v. 161, n. 2, p. 544-551, 2023.
dc.identifier.doi10.1002/ijgo.14552
dc.identifier.issn1879-3479
dc.identifier.issn0020-7292
dc.identifier.scopus2-s2.0-85143385144
dc.identifier.urihttp://hdl.handle.net/11449/247987
dc.language.isoeng
dc.relation.ispartofInternational Journal of Gynecology and Obstetrics
dc.sourceScopus
dc.subjectgestational hypertension
dc.subjectmatrix metalloproteinase-2
dc.subjectpre-eclampsia
dc.subjecttissue inhibitor of metalloproteinase 1
dc.subjecttissue inhibitor of metalloproteinase 3
dc.titleCirculating levels of tissue inhibitor of metalloproteinase 3, a protein with inhibitory effects on angiogenesis, are increased in pre-eclampsiaen
dc.typeArtigo
unesp.author.orcid0000-0002-2669-5301[1]
unesp.author.orcid0000-0002-3273-3001[4]
unesp.author.orcid0000-0002-8990-0237[5]
unesp.author.orcid0000-0001-5010-4914[7]
unesp.author.orcid0000-0002-8041-5753[8]
unesp.author.orcid0000-0002-8331-3525[9]
unesp.author.orcid0000-0002-6168-7470[10]

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Artigos - Física e Biofísica - IBB
Artigos - Ginecologia e Obstetrícia - FMB
Artigos - Química e Bioquímica - IBB
Botucatu - CEATOX - Centro de Assistência Toxicológica