Genome-wide association study for carcass traits in an experimental nelore cattle population

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dc.contributor.authorMedeiros De Oliveira Silva, Rafael [UNESP]
dc.contributor.authorStafuzza, Nedenia Bonvino [UNESP]
dc.contributor.authorFragomeni, Breno De Oliveira
dc.contributor.authorFerreira De Camargo, Gregório Miguel [UNESP]
dc.contributor.authorCeacero, Thaís Matos
dc.contributor.authorCyrillo, Joslaine Noely Dos Santos Gonçalves
dc.contributor.authorBaldi, Fernando [UNESP]
dc.contributor.authorBoligon, Arione Augusti
dc.contributor.authorMercadante, Maria Eugênia Zerlotti
dc.contributor.authorLourenco, Daniela Lino
dc.contributor.authorMisztal, Ignacy
dc.contributor.authorDe Albuquerque, Lucia Galvão [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Georgia
dc.contributor.institutionAnimal Science Institute
dc.contributor.institutionFederal University of Pelotas
dc.date.accessioned2018-12-11T17:09:27Z
dc.date.available2018-12-11T17:09:27Z
dc.date.issued2017-01-01
dc.description.abstractThe purpose of this study was to identify genomic regions associated with carcass traits in an experimental Nelore cattle population. The studied data set contained 2,306 ultrasound records for longissimus muscle area (LMA), 1,832 for backfat thickness (BF), and 1,830 for rump fat thickness (RF). A high-density SNP panel (BovineHD BeadChip assay 700k, Illumina Inc., San Diego, CA) was used for genotyping. After genomic data quality control, 437,197 SNPs from 761 animals were available, of which 721 had phenotypes for LMA, 669 for BF, and 718 for RF. The SNP solutions were estimated using a single-step genomic BLUP approach (ssGWAS), which calculated the variance for windows of 50 consecutive SNPs and the regions that accounted for more than 0.5% of the additive genetic variance were used to search for candidate genes. The results indicated that 12, 18, and 15 different windows were associated to LMA, BF, and RF, respectively. Confirming the polygenic nature of the studied traits, 43, 65, and 53 genes were found in those associated windows, respectively for LMA, BF, and RF. Among the candidate genes, some of them, which already had their functions associated with the expression of energy metabolism, were found associated with fat deposition in this study. In addition, ALKBH3 and HSD17B12 genes, which are related in fibroblast death and metabolism of steroids, were found associated with LMA. The results presented here should help to better understand the genetic and physiologic mechanism regulating the muscle tissue deposition and subcutaneous fat cover expression of Zebu animals. The identification of candidate genes should contribute for Zebu breeding programs in order to consider carcass traits as selection criteria in their genetic evaluation.en
dc.description.affiliationSchool of Agricultural and Veterinarian Sciences FCAV/ UNESP-Sao Paulo State University Department of Animal Science
dc.description.affiliationUniversity of Georgia Department of Animal and Dairy Science
dc.description.affiliationAPTA Center of Beef Cattle Animal Science Institute
dc.description.affiliationDepartment of Animal Science Federal University of Pelotas
dc.description.affiliationUnespSchool of Agricultural and Veterinarian Sciences FCAV/ UNESP-Sao Paulo State University Department of Animal Science
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0169860
dc.identifier.citationPLoS ONE, v. 12, n. 1, 2017.
dc.identifier.doi10.1371/journal.pone.0169860
dc.identifier.file2-s2.0-85010637309.pdf
dc.identifier.issn1932-6203
dc.identifier.scopus2-s2.0-85010637309
dc.identifier.urihttp://hdl.handle.net/11449/174126
dc.language.isoeng
dc.relation.ispartofPLoS ONE
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleGenome-wide association study for carcass traits in an experimental nelore cattle populationen
dc.typeArtigo

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