Alendronate therapy in cyclosporine-induced alveolar bone loss in rats

Página do item simplificado
dc.contributor.authorRossa, C.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:22:56Z
dc.date.available2014-05-20T15:22:56Z
dc.date.issued2007-10-01
dc.description.abstractBackground and Objective: Cyclosporine A is an immunosuppressive drug that is widely used in organ transplant patients as well as to treat a number of autoimmune conditions. Bone loss is reported as a significant side-effect of cyclosporine A use because this can result in serious morbidity of the patients. As we have shown that cyclosporine A-associated bone loss can also affect the alveolar bone, the purpose of this study was to evaluate the effect of the concomitant administration of alendronate on alveolar bone loss in a rat model.Material and Methods: Forty Wistar rats (10 per group) were given cyclosporine A (10 mg/kg, daily), alendronate (0.3 mg/kg, weekly), or both cyclosporine A and alendronate, for 60 d. The control group received daily injections of sterile saline. The expression of proteins associated with bone turnover, including osteocalcin, alkaline phosphatase and tartrate-resistant acid phosphatase (TRAP), and also the calcium levels, were evaluated in the serum. Analysis of the bone volume, alveolar bone surface, the number of osteoblasts per bone surface and the number of osteoclasts per bone surface around the lower first molars was also performed.Results: the results indicate that cyclosporine A treatment was associated with bone resorption, represented by a decrease in the bone volume, alveolar bone surface and the number of osteoblasts per bone surface and by an increase in the number of osteoclasts per bone surface and TRAP-5b. These effects were effectively counteracted by concomitant alendronate administration.Conclusion: It is concluded that concomitant administration of alendronate can prevent cyclosporine A-associated alveolar bone loss.en
dc.description.affiliationState Univ São Paulo, Dent Sch Araraquara, Dept Pathol, São Paulo, Brazil
dc.description.affiliationState Univ São Paulo, Sch Dent Araraquara, Dept Physiol, São Paulo, Brazil
dc.description.affiliationState Univ São Paulo, Sch Dent Araraquara, Dept Periodontol, São Paulo, Brazil
dc.description.affiliationUnespState Univ São Paulo, Dent Sch Araraquara, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnespState Univ São Paulo, Sch Dent Araraquara, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnespState Univ São Paulo, Sch Dent Araraquara, Dept Periodontol, São Paulo, Brazil
dc.format.extent466-473
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0765.2007.00970.x
dc.identifier.citationJournal of Periodontal Research. Oxford: Blackwell Publishing, v. 42, n. 5, p. 466-473, 2007.
dc.identifier.doi10.1111/j.1600-0765.2007.00970.x
dc.identifier.issn0022-3484
dc.identifier.urihttp://hdl.handle.net/11449/33831
dc.identifier.wosWOS:000249421000011
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofJournal of Periodontal Research
dc.relation.ispartofjcr2.878
dc.relation.ispartofsjr0,927
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectalendronatept
dc.subjectalveolar bone losspt
dc.subjectbiochemical markers of bone turnoverpt
dc.subjectcyclosporinept
dc.titleAlendronate therapy in cyclosporine-induced alveolar bone loss in ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Publishing
unesp.author.lattes7634063102292261[1]
unesp.author.orcid0000-0003-1705-5481[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Fisiologia e Patologia - FOAR
Artigos - Diagnóstico e Cirurgia - FOAR