Different patterns of expression of cell cycle control and local invasion-related proteins in oral squamous cell carcinoma affecting young patients

dc.contributor.authorGalvis, Marisol Miranda
dc.contributor.authorSantos-Silva, Alan Roger
dc.contributor.authorJardim, Juscelino Freitas
dc.contributor.authorFonseca, Felipe Paiva
dc.contributor.authorLopes, Marcio A.
dc.contributor.authorAlmeida, Oslei Paes de
dc.contributor.authorLopes Pinto, Clovis A.
dc.contributor.authorKaminagakura, Estela [UNESP]
dc.contributor.authorSawazaki-Calone, Iris
dc.contributor.authorSpeight, Paul M.
dc.contributor.authorKowalski, Luiz Paulo
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniv Sheffield
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionAC Camargo Canc Ctr
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionWestern Parana State Univ
dc.date.accessioned2018-11-26T17:48:19Z
dc.date.available2018-11-26T17:48:19Z
dc.date.issued2018-01-01
dc.description.abstractObjectivesOral squamous cell carcinoma (OSCC) predominantly affects males in the fifth decade of life; nevertheless, an increased incidence in young patients has been reported worldwide, and the clinical and behavioral characteristics of tumors in this group are controversial, and the literature shows divergent results. PurposeTo investigate the clinicopathological features and prognostic significance of the immunoexpression of cell cycle and local invasion proteins in OSCC affecting young patients (40years old). MethodsA tissue microarray was performed with 132 OSCC samples (61 cases of young patients vs 71 cases of elderly patients) and submitted to immunohistochemical reactions with Ki67, p53, p16, Bcl-2, Cyclin D1, C-ErbB2, p21, Myc, EGFR, MMP-9, SMA, Cathepsin K and FGF-2 antibodies. ResultsClinicopathological features and survival rates were similar in both groups. Although overexpression of EGFR (P=.042) and MMP-9 (P=.001) was more frequent in young patients, only C-ErbB-2 (P=.048) and SMA (P=.048) expression correlated with lower disease-free survival (DFS) in this group of patients. ConclusionClinicopathological features and survival rates are similar between younger and older patients with OSCC. The different patterns of C-ErbB2, EGFR, MMP-9, and SMA expression between the groups merits further investigation to understand their role in the early tumor onset in young patients.en
dc.description.affiliationUniv Estadual Campinas, Dept Oral Diag, Piracicaba Dent Sch, Piracicaba, Brazil
dc.description.affiliationUniv Sheffield, Acad Unit Oral & Maxillofacial Pathol, Sch Clin Dent, Sheffield, S Yorkshire, England
dc.description.affiliationUniv Fed Minas Gerais, Dept Oral Surg & Pathol, Sch Dent, Belo Horizonte, MG, Brazil
dc.description.affiliationAC Camargo Canc Ctr, Dept Anat Pathol, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Jose Dos Campos, Brazil
dc.description.affiliationWestern Parana State Univ, Oral Pathol & Oral Med Dent Sch, Cascavel, Brazil
dc.description.affiliationAC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Jose Dos Campos, Brazil
dc.description.sponsorshipBrazilian Coordination of Higher Education
dc.format.extent32-39
dc.identifierhttp://dx.doi.org/10.1111/jop.12601
dc.identifier.citationJournal Of Oral Pathology & Medicine. Hoboken: Wiley, v. 47, n. 1, p. 32-39, 2018.
dc.identifier.doi10.1111/jop.12601
dc.identifier.issn0904-2512
dc.identifier.urihttp://hdl.handle.net/11449/163890
dc.identifier.wosWOS:000425831300006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Oral Pathology & Medicine
dc.relation.ispartofsjr0,791
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcell cycle proteins
dc.subjectclinicopathologic characteristics
dc.subjectlocal invasion proteins
dc.subjectoral squamous cell carcinoma
dc.titleDifferent patterns of expression of cell cycle control and local invasion-related proteins in oral squamous cell carcinoma affecting young patientsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.orcid0000-0003-2040-6617[2]

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