Chemopreventive activity of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide

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dc.contributor.authorPidone Ribeiro, Flavia Andressa
dc.contributor.authorGomes de Moura, Carolina Foot
dc.contributor.authorBoiago Gollucke, Andrea Pitelli
dc.contributor.authorFerreira, Monica Siqueira
dc.contributor.authorCatharino, Rodrigo Ramos
dc.contributor.authorAguiar, Odair
dc.contributor.authorSpadari, Regina Celia
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.contributor.authorRibeiro, Daniel Araki
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCatholic Santos Univ
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:10:56Z
dc.date.available2014-12-03T13:10:56Z
dc.date.issued2014-08-01
dc.description.abstractObjective: The aim of this study was to evaluate the chemopreventive activity of an apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide (4NQO).Methods: A total of 30 male Wistar rats were distributed into five groups as follows (n = 6 per group): Group 1, negative control group (non-treated group); Group 2, received 4NQO during 8 weeks in drinking water and treated with apple extract at 1% by gavage between the first and fourth weeks daily (initiation phase); Group 3, received 4NQO for 8 weeks in drinking water and treated with apple extract by gavage at 1% between the fifth and eighth weeks daily (promotion phase); Group 4, received apple extract at 1% by gavage for 8 consecutive weeks only; and Group 5, received 4NQO for 8 weeks in drinking water daily.Results: Histopathological analysis revealed decreased hyperplasic lesions in Group 2 when compared with Group 5. Likewise, decreased dysplastic lesions in Group 3 were observed when compared with Group 5. In Groups 2 and 3, decreased COX-2 and TNF-alpha gene expressions were observed when compared with Group 5. Cytochrome c and caspase 3 levels increased in Groups 2 and 3 when compared with Group 5.Conclusion: In conclusion, our results demonstrate that apple extract suppresses rat tongue carcinogenesis as a result of anti-inflammatory activity and apoptosis through the intrinsic mitochondrial pathway. (C) 2014 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Pathol, BR-11060001 Santos, SP, Brazil
dc.description.affiliationCatholic Santos Univ, Hexalab, Santos, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Med & Expt Surg Nucleus, INNOVARE Biomarkers Lab, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biosci, Dept Morphol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biosci, Dept Morphol, Botucatu, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent815-821
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2014.04.013
dc.identifier.citationArchives Of Oral Biology. Oxford: Pergamon-elsevier Science Ltd, v. 59, n. 8, p. 815-821, 2014.
dc.identifier.doi10.1016/j.archoralbio.2014.04.013
dc.identifier.issn0003-9969
dc.identifier.lattes3278528112652257
dc.identifier.urihttp://hdl.handle.net/11449/112658
dc.identifier.wosWOS:000338822300007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofArchives of Oral Biology
dc.relation.ispartofjcr2.050
dc.relation.ispartofsjr0,752
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectApple extracten
dc.subject4-Nitroquinoline-1-oxideen
dc.subjectOral canceren
dc.subjectInflammationen
dc.subjectApoptosisen
dc.titleChemopreventive activity of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxideen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3278528112652257
unesp.author.orcid0000-0001-7219-2644[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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