Avaliação de Hb A2 e Hb F em doadores de sangue de região malarígena da Amazônia Oriental brasileira por HPLC

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dc.contributor.authorSouza, Wanessa C. [UNESP]
dc.contributor.authorTorres, Felipe R. [UNESP]
dc.contributor.authorSalvador, Ana R. [UNESP]
dc.contributor.authorTávora, Juvanete A.
dc.contributor.authorMachado, Ricardo L. D.
dc.contributor.authorBonini-Domingos, Cláudia R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionHemocentro do Amapá
dc.date.accessioned2014-05-20T14:00:34Z
dc.date.available2014-05-20T14:00:34Z
dc.date.issued2003-01-01
dc.description.abstractIn malaria endemic regions of Africa, resistance to infection by Plasmodium has been observed in under 6-month-old children, when there are higher fetal hemoglobin (Hb F) levels. Research performed in the São José do Rio Preto region, central-east Brazil, reported increased levels of Hb F in blood donors. The purpose of this work was to evaluate the A2 hemoglobin (Hb A2) and Hb F concentrations in blood donors deriving from the Brazilian malaria endemic region. Forty-five blood donor samples from Macapá, from patients with varying genders, ages and ethnic origins, were collected by venous puncture after informed consent was obtained. The samples were analyzed by High Performance Liquid Chromatography (HPLC) - System Variant (Bio-Rad). The HPLC demonstrated sensitivity and rapidity in the identification and measurement of the hemoglobins and gave precise results. Moreover, it provided measurement of hemoglobin variants, even when they were present in small amounts, providing a diagnosis of hemoglobinopathies. Hb F levels above the normal were observed in 33.3% of the analyzed samples. The presence of increased Hb F can suggest resistance to infection by Plasmodium falciparum, as there have been reports that infected red blood cells interfere in the development of the parasite.en
dc.description.affiliationUniversidade Estadual Paulista Departamento de Biologia Laboratório de Hemoglobinas e Genética das Doenças Hematológicas
dc.description.affiliationFaculdade de Medicina de São José do Rio Preto (FAMERP) Centro de Investigação de Microorganismos
dc.description.affiliationHemocentro do Amapá
dc.description.affiliationUnespUniversidade Estadual Paulista Departamento de Biologia Laboratório de Hemoglobinas e Genética das Doenças Hematológicas
dc.format.extent263-265
dc.identifierhttp://dx.doi.org/10.1590/S1516-84842003000400013
dc.identifier.citationRevista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, v. 25, n. 4, p. 263-265, 2003.
dc.identifier.doi10.1590/S1516-84842003000400013
dc.identifier.fileS1516-84842003000400013.pdf
dc.identifier.issn1516-8484
dc.identifier.lattes3279428066176719
dc.identifier.orcid0000-0002-4603-9467
dc.identifier.scieloS1516-84842003000400013
dc.identifier.urihttp://hdl.handle.net/11449/21420
dc.language.isopor
dc.publisherAssociação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea
dc.relation.ispartofRevista Brasileira de Hematologia e Hemoterapia
dc.relation.ispartofsjr0,335
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectHemoglobin Sen
dc.subjectMalariaen
dc.subjectGenetic polymorphismen
dc.subjectBlood donorsen
dc.subjectAmazon regionen
dc.titleAvaliação de Hb A2 e Hb F em doadores de sangue de região malarígena da Amazônia Oriental brasileira por HPLCpt
dc.title.alternativeEvaluation of Hb A2 and Hb F by HPLC in blood donors from the malaria endemic region of Eastern Amazon of Brazilen
dc.typeArtigo
unesp.author.lattes3279428066176719[6]
unesp.author.orcid0000-0002-4603-9467[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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Artigos - Biologia - IBILCE