Chemosensory control by commissural nucleus of the solitary tract in rats

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dc.contributor.authorFavero, Michele T. [UNESP]
dc.contributor.authorTakakura, Ana C.
dc.contributor.authorde Paula, Patricia M. [UNESP]
dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorMoreira, Thiago S.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:46:16Z
dc.date.available2014-05-20T13:46:16Z
dc.date.issued2011-12-15
dc.description.abstractThe commissural nucleus of the solitary tract (commNTS) is a main area that receives afferent signals involved in the cardiovascular and respiratory control like those related to chemoreceptor activation. however, the importance of the commNTS for the cardiorespiratory responses to chemoreceptor activation is still controversial. In the present study, we investigated the cardiorespiratory responses to hypoxia or hypercapnia in anesthetized and conscious rats treated with injections of the GABA-A agonist muscimol into the caudal portion of the commNTS. Male :Holtzman rats (280-300g) were used. In conscious rats that had a stainless steel cannula previously implanted into the commNTS, the injection of muscimol (2 mM) into the commNTS reduced the pressor response (16 +/- 2 mmHg, vs. saline: 36 +/- 3 mmHg) and the increase in ventilation (250 +/- 17 ml/min/kg, vs. saline: 641 +/- 28 ml/min/kg) produced by hypoxia (8-10% O(2)). In urethane anesthetized rats, the injection of muscimol into the commNTS eliminated the pressor response (5 +/- 2 mmHg, vs. saline: 26 +/- 5 mmHg) and the increase in phrenic nerve discharge (PND) (20 +/- 6%, vs. saline: 149 +/- 15%) and reduced the increase in splanchnic sympathetic nerve discharge (sSND) (93 +/- 15%, vs. saline: 283 +/- 19% of baseline) produced by hypoxia. However, muscimol injected into the commNTS did not change hypercapnia (8-10% CO(2)) induced pressor response or the increase in the sSND or PND in urethane anesthetized rats or the increase in ventilation in conscious rats. The present results suggest that the cardiorespiratory responses to hypoxia are strongly dependent on the caudal portion of the commNTS, however, this area is not involved in the responses to hypercapnia. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 06/60174-9
dc.description.sponsorshipIdFAPESP: 10/09776-3
dc.format.extent227-234
dc.identifierhttp://dx.doi.org/10.1016/j.resp.2011.08.010
dc.identifier.citationRespiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 179, n. 2-3, p. 227-234, 2011.
dc.identifier.doi10.1016/j.resp.2011.08.010
dc.identifier.fileWOS000297903500022.pdf
dc.identifier.issn1569-9048
dc.identifier.lattes4544450092427426
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/16347
dc.identifier.wosWOS:000297903500022
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRespiratory Physiology & Neurobiology
dc.relation.ispartofjcr1.792
dc.relation.ispartofsjr0,682
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectCentral and peripheral chemoreflexen
dc.subjectBreathingen
dc.subjectSympathetic activityen
dc.subjectNTSen
dc.subjectHypoxiaen
dc.titleChemosensory control by commissural nucleus of the solitary tract in ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes4544450092427426[4]
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0001-5433-4493[3]
unesp.author.orcid0000-0002-1395-4036[4]
unesp.author.orcid0000-0003-1167-4441[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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