Usefulness of Mycobacterium tuberculosis molecular typing in a tuberculosis low-endemic agro-industrial setting of Brazil

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dc.contributor.authorMalaspina, Ana Carolina [UNESP]
dc.contributor.authorCavalcanti, Hebe Rodrigues
dc.contributor.authorLeite, Clarice Queico Fujimura [UNESP]
dc.contributor.authorMachado, Silvia Maria Almeida
dc.contributor.authorViana, Brunilde Helena Jung
dc.contributor.authorSilva, Rosangela Maria Gaspareto
dc.contributor.authorHage, Eduardo Ferraz
dc.contributor.authorFigueiredo, Walter Machado
dc.contributor.authorMarques, Elisabeth
dc.contributor.authorFerrazoli, Lucilaine
dc.contributor.authorArbex, Marcos
dc.contributor.authorLessi, Marcio
dc.contributor.authorFonseca, Leila S.
dc.contributor.authorRigouts, Leen
dc.contributor.authorSaad, Maria Helena Féres [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionInstituto Oswaldo Cruz/Fiocruz
dc.contributor.institutionAmérico Brasilienses
dc.contributor.institutionInstitut of Tropical Medicine
dc.date.accessioned2014-05-27T11:23:36Z
dc.date.available2014-05-27T11:23:36Z
dc.date.issued2008-07-02
dc.description.abstractTo highlight the transmission and major phylogenetic clades of Mycobacterium tuberculosis, a retrospective study was carried out at two health facilities in a small agro-industrial area in São Paulo, Brazil, that has a low tuberculosis incidence rate. IS6110-RFLP and spoligotyping were performed on the isolates, with the former revealing that 31.3% (35/112) of strains were clustered. Epidemiological links were found in 16 of the 35 clustered patients and were associated with transmission among patients living in public housing. Spoligotyping grouped 62.8% of the strains. The T genetic family predominated among the isolates. Of interest is that five strains had a pattern characteristic of African or Asian origin (ST535), and two others were of the rare localized type ST1888 (BRA, VEN). In addition, three new types-1889, 1890, and 1891-were identified. Spoligotyping showed that some ST may be circulating to or from Brazil, and RFLP revealed ongoing transmission in inadequately ventilated public-housing buildings. This may point to a failure in tuberculosis control policy.en
dc.description.affiliationFaculdade de Ciéncias Farmacêuticas Universidade Estadual Paulista, São Paulo
dc.description.affiliationHospital Universitário Pedro Ernesto Universidade Federal do Rio de Janeiro, Rio de Janeiro
dc.description.affiliationLaboratório de Microbiologia Celular Instituto Oswaldo Cruz/Fiocruz, Av. Brasil 4365, Rio de Janeiro 21045-900
dc.description.affiliationServiço Especial de Saúde de Araraquara Américo Brasilienses, São Paulo
dc.description.affiliationInstituto Adolfo Lutz Américo Brasilienses, São Paulo
dc.description.affiliationInstituto de Microbiologia Universidade Federal do Rio de Janeiro, Rio de Janeiro
dc.description.affiliationHospital Nestor Goulart Reis Américo Brasilienses, São Paulo
dc.description.affiliationInstitut of Tropical Medicine, Antwerp
dc.description.affiliationUnespFaculdade de Ciéncias Farmacêuticas Universidade Estadual Paulista, São Paulo
dc.format.extent231-233
dc.identifierhttp://www0.nih.go.jp/JJID/61/231.pdf
dc.identifier.citationJapanese Journal of Infectious Diseases, v. 61, n. 3, p. 231-233, 2008.
dc.identifier.file2-s2.0-45849084706.pdf
dc.identifier.issn1344-6304
dc.identifier.lattes2114570774349859
dc.identifier.scopus2-s2.0-45849084706
dc.identifier.urihttp://hdl.handle.net/11449/70473
dc.language.isoeng
dc.relation.ispartofJapanese Journal of Infectious Diseases
dc.relation.ispartofjcr1.014
dc.relation.ispartofsjr0,595
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectpyrazinamide
dc.subjectstreptomycin
dc.subjectAfrica
dc.subjectAsia
dc.subjectbacterial strain
dc.subjectbacterial transmission
dc.subjectbacterium isolate
dc.subjectBrazil
dc.subjectcommunity living
dc.subjectdrug sensitivity
dc.subjectgeographic origin
dc.subjecthealth care facility
dc.subjecthuman
dc.subjectincidence
dc.subjectindustrial area
dc.subjectmolecular typing
dc.subjectMycobacterium tuberculosis
dc.subjectrestriction fragment length polymorphism
dc.subjectretrospective study
dc.subjectspoligotyping
dc.subjectstrain identification
dc.subjecttuberculosis
dc.subjectDNA Transposable Elements
dc.subjectFemale
dc.subjectHumans
dc.subjectIncidence
dc.subjectMale
dc.subjectOligonucleotides
dc.subjectPolymorphism, Restriction Fragment Length
dc.subjectPublic Housing
dc.subjectTuberculosis, Pulmonary
dc.titleUsefulness of Mycobacterium tuberculosis molecular typing in a tuberculosis low-endemic agro-industrial setting of Brazilen
dc.typeArtigo
unesp.author.lattes2114570774349859
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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