Vocal Folds Leukoplakia: The Efficacy of Vitamin a in the Initial Treatment

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dc.contributor.authorBotini, Dayane Silvestre [UNESP]
dc.contributor.authorRodrigues, Sergio Augusto [UNESP]
dc.contributor.authorCastilho, Gustavo Leao [UNESP]
dc.contributor.authorMercuri, Gustavo [UNESP]
dc.contributor.authorMartins, Regina Helena Garcia [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T11:56:32Z
dc.date.available2023-07-29T11:56:32Z
dc.date.issued2022-11-10
dc.description.abstractIntroduction Laryngeal leukoplakia corresponds to a white lesion in the mucosa developed by the deposit of keratin in the epithelium, potentiated by chronic smoking. It is considered a preneoplastic lesion. Surgery is the most adopted treatment; however, non-surgical treatment is advocated by some authors. Objective To evaluate the effectiveness of vitamin A in the management of vocal fold leukoplakia. Methods Patients with videolaryngoscopy diagnosis of vocal fold leukoplakia were selected. The endoscopic images were photographed and with the aid of the ImageJ software (National Institutes of Health, Bethesda, MD, USA), the proportion of the size of the leukoplakia was calculated. Eligible patients were prescribed 50,000U of vitamin A, twice daily for 2 months, at which point videolaryngostroboscopy was repeated for comparative analysis between pre and posttreatment. The efficacy of the treatment was classified as: outcome I - complete improvement of the lesion, outcome II - partial improvement, and outcome III - no difference or increased lesion size. Results Fifteen patients (eight women, seven men) were included, six of whom had bilateral lesions. Smoking was reported in 86.8% of patients. Complete improvement of the lesion was found in 7 cases (33.4%, outcome I), partial improvement in 6 (28.6%, outcome II), and worsening of the injury in 8 (38.1%, outcome III). Of the latter, 6 underwent microsurgery; histopathology indicated absence of dysplasia in 3, and mild dysplasia in 3. Conclusions In this study, the treatment with vitamin A at a dose of 100,000IU daily for 2 months was effective in reducing the laryngeal leukoplakia size in 62% of cases.en
dc.description.affiliationUniv Estadual Paulista Unesp, Ophthalmol Otorhinolaryngol Head & Neck Surg Dept, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Unesp, Biostat Dept, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Botucatu Med Sch, Ophthalmol Otorhinolaryngol & Head Neck Surg Dept, Dist Rubiao Jr S-N, BR-18618970 Brasilia, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Unesp, Ophthalmol Otorhinolaryngol Head & Neck Surg Dept, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Unesp, Biostat Dept, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu Med Sch, Ophthalmol Otorhinolaryngol & Head Neck Surg Dept, Dist Rubiao Jr S-N, BR-18618970 Brasilia, SP, Brazil
dc.format.extent97-103
dc.identifierhttp://dx.doi.org/10.1055/s-0042-1742767
dc.identifier.citationInternational Archives of Otorhinolaryngology. Stuttgart: Georg Thieme Verlag Kg, v. 27, n. 01, p. 97-103, 2023.
dc.identifier.doi10.1055/s-0042-1742767
dc.identifier.issn1809-9777
dc.identifier.urihttp://hdl.handle.net/11449/245494
dc.identifier.wosWOS:000884217600001
dc.language.isoeng
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofInternational Archives Of Otorhinolaryngology
dc.sourceWeb of Science
dc.subjectleukoplakia
dc.subjectvocal folds
dc.subjectlarynx
dc.subjectvitamin A
dc.subjecttreatment
dc.titleVocal Folds Leukoplakia: The Efficacy of Vitamin a in the Initial Treatmenten
dc.typeArtigo
dcterms.rightsHolderGeorg Thieme Verlag Kg
unesp.author.orcid0000-0002-2091-2141[2]
unesp.author.orcid0000-0003-0772-1962[5]

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