Spliceosomal factors are recognized by Chagasic sera

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dc.contributor.authorCicarelli, RMB
dc.contributor.authorCastro, LIR
dc.contributor.authorMartins, E. C.
dc.contributor.authorCegatti, M. B.
dc.contributor.authorBahia, D.
dc.contributor.authorBach-Elias, M.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:22Z
dc.date.available2014-05-20T13:24:22Z
dc.date.issued1998-01-01
dc.description.abstractWe investigated the possibility that Chagas' patients develop an autoimmune response to human UsnRNPs or Sm epitopes. Using purified human UsnRNPs we detected anti-human UsnRNPs antibodies in sera from patients with Chagas' disease. The antibodies were also detected using peptide-ELISA containing the Sm-motif 1 domain, showing that 61% (31/51) of the Chagas sera contained antibodies against the Sm-motif 1. Our preliminary results obtained by immunoprecipitation using Chagas chronically infected Balb/C sera and HeLa nuclear extracts showed that some autoantibodies could also be found during the course of the disease. Groups of 20 mice tone-month-old) were infected i.p. with Y strain 30 bloodstream trypomastigotes and killed at 60 days post-infection and sera were used for immunoprecipitation analysis as mentioned, These antibodies cross-reacted with U2 snRNP in HeLa nuclear extract and revealed many different bands in T. cruzi nuclear extract. These results suggest that the autoantibodies may have a role in the pathogenesis of the disease,en
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut, Dept Biol Sci, Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut, Dept Biol Sci, Araraquara, SP, Brazil
dc.format.extent1141-1145
dc.identifierhttp://getinfo.de/app/Microstructural-characterization-of-Ti-added-ultra/id/BLCP%3ACN030942406
dc.identifier.citation10th International Congress on Immunology, Vols 1 and 2. 40128 Bologna: Medimond S R L, p. 1141-1145, 1998.
dc.identifier.urihttp://hdl.handle.net/11449/7531
dc.identifier.wosWOS:000077938500189
dc.language.isoeng
dc.publisherMedimond S R L
dc.relation.ispartof10th International Congress on Immunology, Vols 1 and 2
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleSpliceosomal factors are recognized by Chagasic seraen
dc.typeTrabalho apresentado em evento
dcterms.rightsHolderMedimond S R L
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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