Cardiorespiratory and endocrine effects of endogenous opioid antagonism by naloxone in ponies anaesthetised with halothane

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dc.contributor.authorLuna, SPL
dc.contributor.authorTaylor, P. M.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Cambridge
dc.date.accessioned2014-05-20T13:31:53Z
dc.date.available2014-05-20T13:31:53Z
dc.date.issued2001-04-01
dc.description.abstractHalothane depresses cardiorespiratory function and activates the pituitary-adrenal axis, increasing beta endorphin. In horses, beta endorphin may enhance the anaesthetic-associated cardiorespiratory depression and mortality risk. The authors studied endogenous opioid effects on cardiorespiratory function and pituitary-adrenal activity in halothane-anaesthetised ponies by investigating opioid antagonism by naloxone. Six ponies were anaesthetised three times (crossover design). Anaesthesia was induced with thiopentone and maintained with 1.2 per cent halothane for 2 hours. Immediately after induction, naloxone was administered either intra venously (0.5 mg kg(-1) bolus then 0.25 mg kg(-1) hour(-1) for 2 hours) or intrathecally (0.5 mg) or was replaced by saline as control. Pulse and respiratory rates, arterial blood gases, cardiac output and plasma cortisol and adrenocorticotrophic hormone (ACTH) concentrations were measured. All groups developed cardiorespiratory depression (40 per cent decrease in cardiac output) and plasma cortisol increased. Plasma ACTH concentration was higher in ponies treated with intrathecal naloxone. Endogenous opioids may inhibit ACTH Secretion, attenuating the stress response to halothane anaesthesia in equidae. (C) 2001 Harcourt Publishers Ltd.en
dc.description.affiliationUNESP, Fac Vet Med & Anim Sci, Dept Vet Surg & Anaesthesiol, FMVZ, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Cambridge, Dept Clin Vet Med, Cambridge CB2 1TN, England
dc.description.affiliationUnespUNESP, Fac Vet Med & Anim Sci, Dept Vet Surg & Anaesthesiol, FMVZ, BR-18618000 Botucatu, SP, Brazil
dc.format.extent95-100
dc.identifierhttp://dx.doi.org/10.1053/rvsc.2000.0444
dc.identifier.citationResearch In Veterinary Science. London: W B Saunders Co Ltd, v. 70, n. 2, p. 95-100, 2001.
dc.identifier.doi10.1053/rvsc.2000.0444
dc.identifier.issn0034-5288
dc.identifier.lattes4473260410099623
dc.identifier.orcid0000-0001-5312-9076
dc.identifier.urihttp://hdl.handle.net/11449/10864
dc.identifier.wosWOS:000168958800001
dc.language.isoeng
dc.publisherW B Saunders Co Ltd
dc.relation.ispartofResearch in Veterinary Science
dc.relation.ispartofjcr1.616
dc.relation.ispartofsjr0,593
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleCardiorespiratory and endocrine effects of endogenous opioid antagonism by naloxone in ponies anaesthetised with halothaneen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderW B Saunders Co Ltd
unesp.author.lattes4473260410099623
unesp.author.orcid0000-0001-5312-9076[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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Artigos - Cirurgia e Anestesiologia Veterinária - FMVZ