In vitro production of bovine embryos: Cumulus/granulosa cell gene expression patterns point to early atresia as beneficial for oocyte competence

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dc.contributor.authorMazzoni, Gianluca
dc.contributor.authorRazza, Eduardo
dc.contributor.authorPedersen, Hanne S.
dc.contributor.authorSecher, Jan
dc.contributor.authorKadarmideen, Haja N.
dc.contributor.authorCallesen, Henrik
dc.contributor.authorStroebech, Lotte
dc.contributor.authorFreude, Kristine
dc.contributor.authorHyttel, Poul
dc.contributor.institutionUniversity of Copenhagen
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionAarhus University
dc.contributor.institutionTechnical University of Denmark
dc.contributor.institutionEmbryoTrans Biotech ApS
dc.date.accessioned2022-04-29T08:45:21Z
dc.date.available2022-04-29T08:45:21Z
dc.date.issued2017-01-01
dc.description.abstractIn vitro production (IVP) of bovine embryos has become widespread technology implemented in cattle breeding and production. Here, we review novel data on cumulus/granulosa cell gene expression, as determined by RNAseq on cellular material from pooled follicular fluids at the single animal level, and relate these finding to previous data on oocyte developmental competence and ultrastructure. The cumulus/granulosa cell gene expression patterns indicate that early follicular atresia is associated with increased blastocyst yield and this hypothesis is supported by previous data on oocyte competence and ultrastructure.en
dc.description.affiliationDepartment of Veterinary and Animal Sciences University of Copenhagen
dc.description.affiliationDepartment of Pharmacology Institute of Bioscience University of São Paulo State, Distrito de Rubião Junior s/n
dc.description.affiliationDepartment of Animal Science Aarhus University
dc.description.affiliationDepartment of Bio and Health Informatics Technical University of Denmark
dc.description.affiliationEmbryoTrans Biotech ApS
dc.format.extent482-489
dc.identifierhttp://dx.doi.org/10.21451/1984-3143-AR990
dc.identifier.citationAnimal Reproduction, v. 14, n. 3, p. 482-489, 2017.
dc.identifier.doi10.21451/1984-3143-AR990
dc.identifier.issn1984-3143
dc.identifier.issn1806-9614
dc.identifier.scopus2-s2.0-85044511925
dc.identifier.urihttp://hdl.handle.net/11449/231415
dc.language.isoeng
dc.relation.ispartofAnimal Reproduction
dc.sourceScopus
dc.subjectAtresia
dc.subjectBiomarkers
dc.subjectCattle
dc.subjectGranulosa cells
dc.subjectIVP
dc.subjectOocyte competence
dc.subjectTranscriptomics
dc.titleIn vitro production of bovine embryos: Cumulus/granulosa cell gene expression patterns point to early atresia as beneficial for oocyte competenceen
dc.typeArtigo

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