Neutrophils, eosinophils, and mast cells in the intestinal wall of dogs naturally infected with Leishmania infantum

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dc.contributor.authorda Silva, Diogo Tiago [UNESP]
dc.contributor.authorAlves, Maria Luana [UNESP]
dc.contributor.authorSpada, Júlio Cesar Pereira [UNESP]
dc.contributor.authorda Silveira, Rita de Cássia Viveiros [UNESP]
dc.contributor.authorOliveira, Trícia Maria Ferreira de Sousa
dc.contributor.authorStarke-Buzetti, Wilma Aparecida [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2019-10-06T16:08:36Z
dc.date.available2019-10-06T16:08:36Z
dc.date.issued2018-10-01
dc.description.abstractVisceral leishmaniasis (VL) is a disease caused by the protozoa Leishmania infantum and can cause an inflammatory reaction in the gastrointestinal tract, however the role of granulocytic cells (neutrophils, eosinophils, and mast cells) in the intestine of dogs infected is not fully understood. We performed a quantitative analysis these cells in the intestinal wall of dogs with canine visceral leishmaniasis (CVL). Twenty dogs were assigned to one of three groups: group 1 (G1, n=8), dogs with CVL and L. infantum amastigotes in the intestine; group 2 (G2, n=9), dogs with CVL but without intestinal amastigotes; and group 3 (G3, n=3), uninfected dogs (control group). Granulocytic cells were counted in the crypt-villus unit (mucosa), submucosa, and muscle layer of the intestinal mucosa. Cell counts were higher in the intestinal wall of dogs from G2 followed by G1 and G3 (p≤0.05). In G1, there was a low inverse correlation between parasite burden of the small intestine and granulocyte counts (r=-0.1, p≤0.01). However, in G2 dogs, mast cell and eosinophil numbers showed positive correlation (r=0.85, p≤0.01). The granulocytic cell hyperplasia observed in the intestine of L. infantum-infected dogs suggests that these cells may be involved in the cell-mediated immune response for parasite elimination.en
dc.description.affiliationDepartamento de Biologia e Ciência Animal Faculdade de Engenharia de Ilha Solteira – FEIS Universidade Estadual Paulista – UNESP
dc.description.affiliationUniversidade de São Paulo – USP
dc.description.affiliationInstituto de Biotechnologia Universidade Estadual Paulista – UNESP
dc.description.affiliationDepartmento de Medicina Veterinária Universidade de São Paulo – USP Faculdade de Engenharia de Alimentos e Ciência Animal – FZEA
dc.description.affiliationUnespDepartamento de Biologia e Ciência Animal Faculdade de Engenharia de Ilha Solteira – FEIS Universidade Estadual Paulista – UNESP
dc.description.affiliationUnespInstituto de Biotechnologia Universidade Estadual Paulista – UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2013/13875-5
dc.format.extent430-438
dc.identifierhttp://dx.doi.org/10.1590/s1984-296120180085
dc.identifier.citationRevista Brasileira de Parasitologia Veterinaria, v. 27, n. 4, p. 430-438, 2018.
dc.identifier.doi10.1590/s1984-296120180085
dc.identifier.fileS1984-29612018000400430.pdf
dc.identifier.issn0103-846X
dc.identifier.scieloS1984-29612018000400430
dc.identifier.scopus2-s2.0-85057982549
dc.identifier.urihttp://hdl.handle.net/11449/188456
dc.language.isoeng
dc.relation.ispartofRevista Brasileira de Parasitologia Veterinaria
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCanine visceral leishmaniasis
dc.subjectGranulocytes
dc.subjectIntestinal tract
dc.titleNeutrophils, eosinophils, and mast cells in the intestinal wall of dogs naturally infected with Leishmania infantumen
dc.titleNeutrófilos, eosinófilos e mastócitos na parede intestinal de cães naturalmente infectados com Leishmania infantumpt
dc.typeArtigo

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Artigos - Biologia e Zootecnia - FEIS