Design of novel iron compounds as potential therapeutic agents against tuberculosis

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dc.contributor.authorBelen Tarallo, M.
dc.contributor.authorUrquiola, Carolina
dc.contributor.authorMonge, Antonio
dc.contributor.authorParajon Costa, Beatriz
dc.contributor.authorRibeiro, Ronny R.
dc.contributor.authorCosta-Filho, Antonio J.
dc.contributor.authorMercader, Roberto C.
dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorLeite, Clarice Queico Fujimura [UNESP]
dc.contributor.authorTorre, Maria H.
dc.contributor.authorGambino, Dinorah
dc.contributor.institutionUniv Republica
dc.contributor.institutionUniv Navarra
dc.contributor.institutionUniv Nacl La Plata
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:33:28Z
dc.date.available2014-05-20T15:33:28Z
dc.date.issued2010-11-01
dc.description.abstractIn the search for new therapeutic tools against tuberculosis two novel iron complexes, [Fe(L-H)3], with 3-aminoquinoxaline-2-carbonitrile N(1),N(4)-dioxide derivatives (L) as ligands, were synthesized, characterized by a combination of techniques, and in vitro evaluated. Results were compared with those previously reported for two analogous iron complexes of other ligands of the same family of quinoxaline derivatives. In addition, the complexes were studied by cyclic voltammetry and EPR spectroscopy. Cyclic voltammograms of the iron compounds showed several cathodic processes which were attributed to the reduction of the metal center (Fe(III)/Fe(II)) and the coordinated ligand. EPR signals were characteristic of magnetically isolated high-spin Fe(III) in a rhombic environment and arise from transitions between m(s) = +/- 1/2 (geff-9) or m(s) = +/- 3/2 (g(eff)similar to 4.3) states. Mossbauer experiments showed hyperfine parameters that are typical of high-spin Fe(III) ions in a not too distorted environment. The novel complexes showed in vitro growth inhibitory activity on Mycobacterium tuberculosis H(37)Rv (ATCC 27294), together with very low unspecific cytotoxicity on eukaryotic cells (cultured murine cell line J774). Both complexes showed higher inhibitory effects on M. tuberculosis than the "second-line" therapeutic drugs. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Republica, Fac Quim, Catedra Quim Inorgan, Montevideo 11800, Uruguay
dc.description.affiliationUniv Navarra, CIFA, E-31080 Pamplona, Spain
dc.description.affiliationUniv Nacl La Plata, Fac Ciencias Exactas, Ctr Quim Inorgan CEQUINOR CONICET UNLP, RA-1900 La Plata, Argentina
dc.description.affiliationUniv São Paulo, Inst Fis Sao Carlos, BR-13560 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Nacl La Plata, Fac Ciencias Exactas, Dept Fis, IFLP CONICET, RA-1900 La Plata, Argentina
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipCYTED
dc.description.sponsorshipPEDECIBA Quimica
dc.description.sponsorshipIdCYTED: RIIDFCM 209RT0380
dc.format.extent1164-1170
dc.identifierhttp://dx.doi.org/10.1016/j.jinorgbio.2010.07.005
dc.identifier.citationJournal of Inorganic Biochemistry. New York: Elsevier B.V., v. 104, n. 11, p. 1164-1170, 2010.
dc.identifier.doi10.1016/j.jinorgbio.2010.07.005
dc.identifier.issn0162-0134
dc.identifier.lattes2114570774349859
dc.identifier.urihttp://hdl.handle.net/11449/42075
dc.identifier.wosWOS:000282193700005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Inorganic Biochemistry
dc.relation.ispartofjcr3.063
dc.relation.ispartofsjr0,743
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectTuberculosisen
dc.subjectIronen
dc.subjectQuinoxaline N(1),N(4)-dioxidesen
dc.subjectMycobacterium tuberculosisen
dc.titleDesign of novel iron compounds as potential therapeutic agents against tuberculosisen
dc.typeArtigo
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2114570774349859
unesp.author.orcid0000-0001-6730-8737[6]
unesp.author.orcid0000-0002-6969-3963[8]
unesp.author.orcid0000-0002-2656-0255[10]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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