Prior exposure to stress delays extinction but does not modify reinstatement of nicotine-induced conditioned place preference

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dc.contributor.authorLeão, Rodrigo M [UNESP]
dc.contributor.authorCruz, Fábio C [UNESP]
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:25:31Z
dc.date.available2014-05-20T13:25:31Z
dc.date.issued2010-06-01
dc.description.abstractStudies in humans suggest that exposure to stress is related to relapse to tobacco use. The reinstatement of conditioned place preference (CPP) provides a simple, noninvasive and easy approach to investigate the mechanisms for drug relapse. The present study investigated whether repeated exposure to stress could change the extinction and reinstatement of nicotine-induced CPP. Adult male Wistar were exposed to restraint-stress for 2 hours/daily for 7 days, while the control-group was left undisturbed during this period. One day after the last stress session the CPP protocol was carried out. Nicotine produced a place preference to the compartment paired with its injections during conditioning (.16 mg/kg, s.c.; four drug sessions). Once established, nicotine place preference was extinguished by alternate exposure to each compartment after a saline injection (four exposures to each compartment). The animals that did not show extinction of CPP were submitted to two other extinction sessions. Following this extinction phase, the reinstatement of place conditioning was investigated following a priming injection of nicotine. Both control and stress groups showed reinstatement of CPP. The percentage of rats from the stress group that extinguished nicotine-CPP in the first and second test was lower as compared to the control group. In conclusion, stress delayed the extinction of the nicotine-induced CPP, but did not modify the reinstatement.en
dc.description.affiliationUniversidade Estadual Paulista
dc.description.affiliationUnespUniversidade Estadual Paulista
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent53-57
dc.identifierhttp://www.scielo.br/scielo.php?pid=S1983-32882010000100006&script=sci_arttext
dc.identifier.citationPsychology & Neuroscience. Pontificia Universidade Católica do Rio de JaneiroUniversidade de Brasília (UnB)Universidade de São Paulo, v. 3, n. 1, p. 53-57, 2010.
dc.identifier.doi10.3922/j.psns.2010.1.006
dc.identifier.fileS1983-32882010000100006.pdf
dc.identifier.issn1983-3288
dc.identifier.lattes2514762545280942
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.scieloS1983-32882010000100006
dc.identifier.urihttp://hdl.handle.net/11449/8087
dc.language.isoeng
dc.publisherPontifícia Universidade Católica do Rio de Janeiro (PUC-Rio)
dc.publisherUniversidade de Brasília (UnB)
dc.publisherUniversidade de São Paulo (USP)
dc.relation.ispartofPsychology & Neuroscience
dc.relation.ispartofsjr0,245
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.titlePrior exposure to stress delays extinction but does not modify reinstatement of nicotine-induced conditioned place preferenceen
dc.typeArtigo
unesp.author.lattes2514762545280942[3]
unesp.author.orcid0000-0002-1378-6327[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR