Treatment of periodontal disease with an Er,Cr:YSGG laser in rats exposed to cigarette smoke inhalation

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dc.contributor.authorPavone, Chaine [UNESP]
dc.contributor.authorNogueira, Andressa Vilas Boas [UNESP]
dc.contributor.authorOliveira, Guilherme José Pimentel Lopes de[UNESP]
dc.contributor.authorScardueli, Cássio Rocha [UNESP]
dc.contributor.authorCerri, Paulo Sérgio [UNESP]
dc.contributor.authorMarcantonio Júnior, Elcio [UNESP]
dc.contributor.authorMarcantonio, Rosemary Adriana Chiérici [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-08-06T16:12:46Z
dc.date.available2015-08-06T16:12:46Z
dc.date.issued2015
dc.description.abstractThe purpose of this study was to evaluate the erbium, chromium:yttrium-scandiumgallium-garnet (Er,Cr:YSGG) laser irradiation in the treatment of periodontitis in rats exposed to cigarette smoke inhalation (CSI). Ligatures were placed in the maxillary second molars. After a 15-day period, the ligatures were removed and 180 animals were randomly divided into six groups: (1) CSRP group—CSI and manual scaling and root planing (SRP) treatment; (2) CL group—CSI and Er,Cr:YSGG laser irradiation; (3) CSRP + L group—CSI, SRP, and Er,Cr:YSGG irradiation; (4) SRP group—manual SRP; (5) L group—Er,Cr:YSGG irradiation; (6) SRP + L group—SRP and Er,Cr:YSGG irradiation. At 7, 15, and 30 days after treatments, animals were euthanized and histologic, histometric, immunohistochemistry, and real-time PCR analyses were performed. Histometrically, no differences were observed in the SRP, L, and SRP + L groups exposed to CSI. The CSRP group showed more bone formation at 30 days than at 15 days (p < 0.01) but less bone at 30 days than the CL group at 30 days (p < 0.05). Immunohistochemical staining was positive for osteoblasts, fibroblasts, and osteoclasts. Real-time PCR showed more (vascular endothelial growth factor) VEGF expression in the L (p < 0.05) and SRP + L (p < 0.01) groups at 30 days than at 15 days and less VEGF expression in the CSRP group at 30 days than at 15 days (p < 0.05). There was no difference in fibroblast growth factor (FGF) expression. The Er,Cr:YSGG laser irradiation promotes favorable conditions for tissue repair even in animals exposed to CSI, with similar results as those achieved from manual scaling and root planing.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, Araraquara, RUA HUMAITÁ Nº 1680, CENTRO, CEP 14801903, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, Araraquara, RUA HUMAITÁ Nº 1680, CENTRO, CEP 14801903, SP, Brasil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2009/17639-9
dc.description.sponsorshipIdFAPESP: 2010/16661-8
dc.format.extent1-9
dc.identifierhttp://link.springer.com/article/10.1007%2Fs10103-015-1731-8
dc.identifier.citationLasers in Medical Science, p. 1-9, 2015.
dc.identifier.doi10.1007/s10103-015-1731-8
dc.identifier.issn0268-8921
dc.identifier.lattes3278495911207882
dc.identifier.lattes6100859465871929
dc.identifier.lattes3534044399884035
dc.identifier.orcid0000-0001-5756-5828
dc.identifier.urihttp://hdl.handle.net/11449/125667
dc.language.isoeng
dc.relation.ispartofLasers in Medical Science
dc.relation.ispartofjcr1.949
dc.relation.ispartofsjr0,713
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectEr,Cr:YSGGen
dc.subjectPeriodontal diseaseen
dc.subjectSmokeen
dc.subjectLaseren
dc.titleTreatment of periodontal disease with an Er,Cr:YSGG laser in rats exposed to cigarette smoke inhalationen
dc.typeArtigo
unesp.author.lattes3278495911207882[4]
unesp.author.lattes6100859465871929
unesp.author.lattes3534044399884035
unesp.author.orcid0000-0002-5052-7439[6]
unesp.author.orcid0000-0002-9660-4524[5]
unesp.author.orcid0000-0001-5756-5828[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
unesp.departmentDiagnóstico e Cirurgiapt

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