Gestational exposure to continuous light impairs the development of the female reproductive system in adult Wistar rat offspring

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dc.contributor.authorOgo, Fernanda Mithie
dc.contributor.authorSiervo, Glaucia Eloisa Munhoz Lion
dc.contributor.authorPraxedes, Ana Maria
dc.contributor.authorVieira, Henrique Rodrigues
dc.contributor.authorda Silva Scarton, Suellen Ribeiro
dc.contributor.authorBitencourt, Ana Tereza Guimarães
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.authorSimão, Andréa Name Colado
dc.contributor.authorGuerra, Marina Trevizan
dc.contributor.authorde Freitas Mathias, Paulo Cesar
dc.contributor.authorFernandes, Glaura Scantamburlo Alves
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionState University of Maringá
dc.contributor.institutionState University of Western Parana
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.date.accessioned2023-07-29T16:09:19Z
dc.date.available2023-07-29T16:09:19Z
dc.date.issued2023-04-15
dc.description.abstractIntroduction: It has been suggested that maternal exposure to constant light during the gestational period could be considered as a chronic stressor, impairing offspring development by interfering in neuroendocrine and behavior responses. Objective: This study aimed to evaluate whether maternal exposure to continuous light during pregnancy affects the adult reproductive system in the female offspring. Materials and Methods: Pregnant Wistar rats were allocated into light–dark (LD) group, exposed to light and dark photoperiod during gestation, and the light–light (LL) group, exposed to a photoperiod of constant light during gestation. After birth, pups were maintained under normal light–dark photoperiod until adulthood. At postnatal day 90, blood was collected from the female offspring, to analyze plasma luteinizing hormone (LH) and progesterone levels, and the uterus and ovaries were harvested for morphometric, histological, and oxidative stress evaluations. Results and Discussion: Female exposure to continuous light during the intrauterine period resulted in the adult reduction of LH and increased progesterone plasma levels, and uterine injuries a higher number of endometrial glands and reduced levels of antioxidant enzymes, such as glutathione reductase and glutathione S-transferase. In these experimental conditions, gestational continuous light exposure disturbs sex hormone balance and reduces the antioxidant enzymatic activity in the uterus of female offspring in adult life.en
dc.description.affiliationDepartment of General Biology Biological Sciences Center State University of Londrina – UEL
dc.description.affiliationDepartment of Pathological Sciences Biological Sciences Center State University of Londrina – UEL
dc.description.affiliationLaboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology State University of Maringá
dc.description.affiliationDepartment of Biological and Health Sciences State University of Western Parana
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista – Botucatu (UNESP)
dc.description.affiliationDepartment of Pathology Clinical Analysis and Toxicology Health Center State University of Londrina – UEL
dc.description.affiliationDepartment of Cell Biology Embryology and Histology Federal University of Mato Grosso do Sul – UFMS
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista – Botucatu (UNESP)
dc.format.extent710-721
dc.identifierhttp://dx.doi.org/10.1002/bdr2.2161
dc.identifier.citationBirth Defects Research, v. 115, n. 7, p. 710-721, 2023.
dc.identifier.doi10.1002/bdr2.2161
dc.identifier.issn2472-1727
dc.identifier.scopus2-s2.0-85150826574
dc.identifier.urihttp://hdl.handle.net/11449/249791
dc.language.isoeng
dc.relation.ispartofBirth Defects Research
dc.sourceScopus
dc.subjectcontinuous light
dc.subjectfemale reproductive development
dc.subjectgestation
dc.subjectoxidative stress
dc.subjectprogesterone
dc.titleGestational exposure to continuous light impairs the development of the female reproductive system in adult Wistar rat offspringen
dc.typeArtigo
unesp.author.orcid0000-0002-5230-6912[1]
unesp.author.orcid0000-0003-2084-4203[2]
unesp.author.orcid0000-0002-7543-1740[4]
unesp.author.orcid0000-0002-3547-6389[5]
unesp.author.orcid0000-0002-3633-6484[6]
unesp.author.orcid0000-0002-2373-9399[7]
unesp.author.orcid0000-0002-2073-6782[8]
unesp.author.orcid0000-0003-0659-0729[9]
unesp.author.orcid0000-0001-6994-4585[10]
unesp.author.orcid0000-0002-6043-1131[11]

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