Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma

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dc.contributor.authorDourado, Mauricio Rocha
dc.contributor.authorElseragy, Amr
dc.contributor.authorda Costa, Bruno Cesar
dc.contributor.authorTéo, Fábio Haach
dc.contributor.authorGuimarães, Gustavo Narvaes
dc.contributor.authorMachado, Renato Assis
dc.contributor.authorRisteli, Maija
dc.contributor.authorWahbi, Wafa
dc.contributor.authorGurgel Rocha, Clarissa Araujo
dc.contributor.authorParanaíba, Lívia Máris Ribeiro
dc.contributor.authorGonzález-Arriagada, Wilfredo Alejandro
dc.contributor.authorda Silva, Sabrina Daniela
dc.contributor.authorRangel, Ana Lucia Carrinho Ayroza
dc.contributor.authorMarques, Marcelo Rocha
dc.contributor.authorRossa Junior, Carlos [UNESP]
dc.contributor.authorSalo, Tuula
dc.contributor.authorColetta, Ricardo D.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversity of Oulu
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity of Helsinki
dc.contributor.institutionOswaldo Cruz Foundation
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionD’Or Institute for Research and Education (IDOR)
dc.contributor.institutionFederal University of Alfenas
dc.contributor.institutionUniversidad de los Andes
dc.contributor.institutionMcGill University
dc.contributor.institutionWestern Paranaí State University
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:39:24Z
dc.date.available2023-07-29T13:39:24Z
dc.date.issued2023-01-11
dc.description.abstractObjective: Although there have been remarkable achievements in the molecular landscape of oral squamous cell carcinoma (OSCC) in recent years, bringing advances in the understanding of its pathogenesis, development and progression, little has been applied in the prognosis and choosing the optimal treatment. In this study, we explored the influence of the stress induced phosphoprotein 1 (STIP1), which is frequently reported to be highly expressed in many cancers, in OSCCs. Methods: STIP1 expression was assessed in the TCGA database and in two independent cohorts by immunohistochemistry. Knockdown strategy was applied in OSCC cell lines to determine the impact of STIP1 on viability, proliferation, migration and invasion. The zebrafish model was applied for studying tumor formation and metastasis in vivo. The association of STIP1 and miR-218-5p was explored by bioinformatics and mimics transfection. Results: STIP1 was highly expressed in OSCCs and significantly associated with shortened survival and higher risk of recurrence. STIP1 down-regulation decreased proliferation, migration and invasion of tumor cells, and reduced the number of metastases in the Zebrafish model. STIP1 and miR-218-5p were inversely expressed, and the transfection of miR-218-5p mimics into OSCC cells decreased STIP1 levels as well as proliferation, migration and invasion. Conclusion: Our findings show that STIP1 overexpression, which is inversely associated with miR-218-5p levels, contributes to OSCC aggressiveness by controlling proliferation, migration and invasion and is a determinant of poor prognosis.en
dc.description.affiliationDepartment of Oral Diagnosis Graduate Program in Oral Biology Piracicaba Dental School University of Campinas, São Paulo
dc.description.affiliationCancer and Translational Medicine Research Unit Faculty of Medicine and Medical Research Center Oulu University Hospital University of Oulu
dc.description.affiliationDepartment of Biosciences and Graduate Program in Oral Biology Piracicaba Dental School University of Campinas, São Paulo
dc.description.affiliationHospital for Rehabilitation of Craniofacial Anomalies University of São Paulo (HRAC/USP), São Paulo
dc.description.affiliationDepartment of Oral and Maxillofacial Diseases Helsinki University Central Hospital Translational Immunology Research Program (TRIMM) University of Helsinki
dc.description.affiliationGonçalo Moniz Institute Oswaldo Cruz Foundation, Bahia
dc.description.affiliationFederal University of Bahia, Bahia
dc.description.affiliationCenter for Biotechnology and Cell Therapy D’Or Institute for Research and Education (IDOR)
dc.description.affiliationDepartment of Pathology and Parasitology Institute of Biomedical Sciences Federal University of Alfenas, Minas Gerais
dc.description.affiliationFacultad de Odontología Centro de Investigación e Innovación Biomédica (CIIB) Universidad de los Andes
dc.description.affiliationLady Davis Institute for Medical Research and Segal Cancer Center Jewish General Hospital and Department of Otolaryngology-Head and Neck Surgery McGill University
dc.description.affiliationDepartment of Oral Pathology and Oral Medicine Dental School Western Paranaí State University, Paraná
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University (UNESP), São Paulo
dc.description.affiliationHUSLAB Department of Pathology Helsinki University Central Hospital University of Helsinki
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University (UNESP), São Paulo
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 407814/2018-3
dc.identifierhttp://dx.doi.org/10.3389/fonc.2022.1085917
dc.identifier.citationFrontiers in Oncology, v. 12.
dc.identifier.doi10.3389/fonc.2022.1085917
dc.identifier.issn2234-943X
dc.identifier.scopus2-s2.0-85147032185
dc.identifier.urihttp://hdl.handle.net/11449/248278
dc.language.isoeng
dc.relation.ispartofFrontiers in Oncology
dc.sourceScopus
dc.subjectinvasion
dc.subjectMIR-218-5p
dc.subjectoral cancer
dc.subjectprognosis
dc.subjectproliferation
dc.subjectSTIP1
dc.titleStress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinomaen
dc.typeArtigo

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