Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats

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dc.contributor.authorPossomato-Vieira, Jose Sergio [UNESP]
dc.contributor.authorGonçalves-Rizzi, Victor Hugo [UNESP]
dc.contributor.authorGraça, Tamiris Uracs Sales [UNESP]
dc.contributor.authorNascimento, Regina Aparecida [UNESP]
dc.contributor.authorDias-Junior, Carlos A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:05:37Z
dc.date.available2018-12-11T17:05:37Z
dc.date.issued2016-12-01
dc.description.abstractSodium hydrosulfide (NaHS) has presented antihypertensive and antioxidant effects and may reduce circulating soluble fms-like tyrosine kinase-1 (sFlt-1). We examined whether NaHS prevents maternal and fetal detrimental changes in a model of hypertension in pregnancy induced by N(G)-nitro-L-arginine methyl ester (L-NAME). Forty pregnant rats were divided into four groups (n = 10 per group): Norm-Preg, Preg + NaHS, HTN-Preg, or HTN-Preg + NaHS. Systolic blood pressure (SBP), number of viable fetuses, litter size, pups, and placentae weights were recorded. Circulating plasma sFlt-1, vascular endothelial growth factor (VEGF), myeloperoxidase (MPO), trolox equivalent antioxidant capacity (TEAC) levels, and biochemical determinants of nitric oxide (NO) formation were assessed. SBP values were elevated in the HTN-Preg group on gestational days 16, 18, and 20. However, HTN-Preg + NaHS group presented lower SBP values on days 18 and 20. Lower number of viable fetuses and litter size were found only in HTN-Preg group compared to other. Reductions in placental weight were found in HTN-Preg and HTN-Preg + NaHS groups. Increases in fetal weight were found only in Preg + NaHS group. Increases in circulating sFlt-1 and VEGF levels were observed only in HTN-Preg group compared to other. Higher MPO and lower TEAC plasma levels were found in HTN-Preg + NaHS and HTN-Preg groups. NO was diminished in HTN-Preg animals, and NaHS treatment increased NO levels only in hypertensive pregnant animals. Treatment with NaHS prevents hypertension in pregnancy and concomitantly reduces circulating plasma sFlt-1 and VEGF levels; this correlates with improved litter size with more viable fetuses and increase in NO levels. However, these beneficial effects presented no relation with oxidative stress.en
dc.description.affiliationDepartment of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University (UNESP), Distrito de Rubiao Junior S/N, 18.618-970
dc.description.affiliationUnespDepartment of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University (UNESP), Distrito de Rubiao Junior S/N, 18.618-970
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: FAPESP - Brazil
dc.format.extent1325-1332
dc.identifierhttp://dx.doi.org/10.1007/s00210-016-1296-5
dc.identifier.citationNaunyn-Schmiedeberg's Archives of Pharmacology, v. 389, n. 12, p. 1325-1332, 2016.
dc.identifier.doi10.1007/s00210-016-1296-5
dc.identifier.file2-s2.0-84987607009.pdf
dc.identifier.issn1432-1912
dc.identifier.issn0028-1298
dc.identifier.scopus2-s2.0-84987607009
dc.identifier.urihttp://hdl.handle.net/11449/173463
dc.language.isoeng
dc.relation.ispartofNaunyn-Schmiedeberg's Archives of Pharmacology
dc.relation.ispartofsjr0,836
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectHydrogen sulfide donor
dc.subjectN(G)-nitro-L-arginine methyl ester
dc.subjectPreeclampsia
dc.subjectRats
dc.titleSodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant ratsen
dc.typeArtigo
unesp.author.lattes6296664642422599[5]
unesp.author.orcid0000-0002-0348-6144[5]

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