Intestinal anti-inflammatory activity of coumarin and 4-hydroxycoumarin in the trinitrobenzenesulphonic acid model of rat colitis

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dc.contributor.authorLuchini, Ana Carolina [UNESP]
dc.contributor.authorRodrigues-Orsi, Patrícia [UNESP]
dc.contributor.authorCestari, Silvia Helena [UNESP]
dc.contributor.authorSeito, Leonardo Noboru [UNESP]
dc.contributor.authorWitaicenis, Aline [UNESP]
dc.contributor.authorPellizzon, Claudia Helena [UNESP]
dc.contributor.authorDi Stasi, Luiz Cláudio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:23:35Z
dc.date.available2014-05-27T11:23:35Z
dc.date.issued2008-07-01
dc.description.abstractCoumarins represent an important class of phenolic compounds with multiple biological activities, including inhibition of lipidic peroxidation and neutrophil-dependent anion superoxide generation, anti-inflammatory and immunosuppressor actions. All of these proprieties are essential for that a drug may be used in the treatment of inflammatory bowel disease. The present study examined intestinal anti-inflammatory activity of coumarin and its derivative, the 4-hydroxycoumarin on experimental ulcerative colitis in rats. This was performed in two different experimental settings, i.e. when the colonic mucosa is intact or when the mucosa is in process of recovery after an initial insult. The results obtained revealed that the coumarin and 4-hydroxycoumarin, at doses of 5 and 25 mg/kg, significantly attenuated the colonic damage induced by trinitrobenzenesulphonic acid (TNBS) in both situations, as evidenced macroscopically, microscopically and biochemically. This effect was related to an improvement in the colonic oxidative status, since coumarin and 4-hydroxycoumarin prevented the glutathione depletion that occurred as a consequence of the colonic inflammation. © 2008 Pharmaceutical Society of Japan.en
dc.description.affiliationLaboratory of Phytomedicines Department of Pharmacology São Paulo State University (UNESP), Botucatu, 18618-000, SP
dc.description.affiliationDepartament of Morphology Instituto de Biociências São Paulo State University (UNESP), Botucatu, 18618-000, SP
dc.description.affiliationUnespLaboratory of Phytomedicines Department of Pharmacology São Paulo State University (UNESP), Botucatu, 18618-000, SP
dc.description.affiliationUnespDepartament of Morphology Instituto de Biociências São Paulo State University (UNESP), Botucatu, 18618-000, SP
dc.format.extent1343-1350
dc.identifierhttp://dx.doi.org/10.1248/bpb.31.1343
dc.identifier.citationBiological and Pharmaceutical Bulletin, v. 31, n. 7, p. 1343-1350, 2008.
dc.identifier.doi10.1248/bpb.31.1343
dc.identifier.issn0918-6158
dc.identifier.issn1347-5215
dc.identifier.lattes0019393779801069
dc.identifier.lattes1697547325096457
dc.identifier.orcid0000-0002-4494-4180
dc.identifier.scopus2-s2.0-46449087882
dc.identifier.urihttp://hdl.handle.net/11449/70455
dc.identifier.wosWOS:000258169100009
dc.language.isoeng
dc.relation.ispartofBiological and Pharmaceutical Bulletin
dc.relation.ispartofjcr1.694
dc.relation.ispartofsjr0,626
dc.relation.ispartofsjr0,626
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subject4-hydroxycoumarin
dc.subjectColitis relapse
dc.subjectCoumarin
dc.subjectRat colitis
dc.subject4 hydroxycoumarin
dc.subjectcoumarin
dc.subjectglutathione
dc.subjectphenol derivative
dc.subjectsalazosulfapyridine
dc.subjectsuperoxide
dc.subjecttrinitrobenzenesulfonic acid
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantiinflammatory activity
dc.subjectcolon injury
dc.subjectcolon mucosa
dc.subjectcontrolled study
dc.subjectdrug dose comparison
dc.subjectenteritis
dc.subjectlipid peroxidation
dc.subjectmale
dc.subjectneutrophil
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectrat
dc.subjecttreatment outcome
dc.subjectulcerative colitis
dc.subject4-Hydroxycoumarins
dc.subjectAcute Disease
dc.subjectAlkaline Phosphatase
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents
dc.subjectChronic Disease
dc.subjectColitis
dc.subjectColon
dc.subjectCoumarins
dc.subjectDiarrhea
dc.subjectGastrointestinal Agents
dc.subjectGlutathione
dc.subjectMale
dc.subjectOrgan Size
dc.subjectPeroxidase
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectRecurrence
dc.subjectSulfasalazine
dc.subjectTrinitrobenzenesulfonic Acid
dc.titleIntestinal anti-inflammatory activity of coumarin and 4-hydroxycoumarin in the trinitrobenzenesulphonic acid model of rat colitisen
dc.typeArtigo
dcterms.licensehttps://www.jstage.jst.go.jp/pub/html/AY04S120_en.html
unesp.author.lattes1697547325096457
unesp.author.lattes0019393779801069[6]
unesp.author.orcid0000-0002-7864-1073[7]
unesp.author.orcid0000-0002-4494-4180[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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