Anxiolytic-like effects of median raphe nucleus lesion in the elevated T-maze

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dc.contributor.authorAndrade, TGCS
dc.contributor.authorMacedo, CEA
dc.contributor.authorZangrossi, H.
dc.contributor.authorGraeff, F. G.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T15:20:00Z
dc.date.available2014-05-20T15:20:00Z
dc.date.issued2004-08-12
dc.description.abstractThe cell bodies of 5-HT containing neurons that innervate the limbic forebrain are mainly found in the dorsal raphe nucleus and in the median raphe nucleus (MRN). To assess the role of the median raphe nucleus in anxiety, rats bearing either electrolytic or 5-HT-selective neurotoxic lesion of the MRN were tested in the elevated T-maze. This apparatus consists of two opposed open arms perpendicular to one enclosed arm. Two tasks are performed in succession by the same rat in one experimental session, namely inhibitory avoidance of the open arm, taken as a measure of conditioned anxiety and one-way escape from the open arm, considered as a measure of unconditioned fear. The test was performed 7 days after the electrolytic lesion (3 mA, 10 s) or 14 days after the neurotoxic lesion (5,7-DHT, 8 mug/1 mul). The results showed that while the electrolytic lesion impaired both inhibitory avoidance and one-way escape, the neurotoxic lesion impaired only inhibitory avoidance. Therefore, serotonergic pathways originating in the MRN seem to participate in the modulation of conditioned anxiety but not unconditioned fear. Other neurotransmitter systems that either originate in or pass through the MRN may regulate unconditioned fear. (C) 2003 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Dept Ciências Biol, FCLA, BR-19806900 Assis, SP, Brazil
dc.description.affiliationUSP, Lab Psicobiol, Fac Filosofia Ciências & Letras Ribeirao Pret, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUSP, Dept Farmacol, Fac Med, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUSP, Dept Neurol Psiquiatria & Psicol Med, Fac Med, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Ciências Biol, FCLA, BR-19806900 Assis, SP, Brazil
dc.format.extent55-60
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2003.10.036
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 153, n. 1, p. 55-60, 2004.
dc.identifier.doi10.1016/j.bbr.2003.10.036
dc.identifier.issn0166-4328
dc.identifier.urihttp://hdl.handle.net/11449/31367
dc.identifier.wosWOS:000222880600007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.relation.ispartofjcr3.173
dc.relation.ispartofsjr1,413
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmedian raphe nucleuspt
dc.subjectelevated T-mazept
dc.subject5-HTpt
dc.subjectanxietypt
dc.titleAnxiolytic-like effects of median raphe nucleus lesion in the elevated T-mazeen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-7918-8776[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Letras, Assispt

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