Stress-induced reinstatement of amphetamine-conditioned place preference and changes in tyrosine hydroxylase in the nucleus accumbens in adolescent rats

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dc.contributor.authorCruz, Fabio C. [UNESP]
dc.contributor.authorLeao, Rodrigo M. [UNESP]
dc.contributor.authorMarin, Marcelo Tadeu [UNESP]
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:25:34Z
dc.date.available2014-05-20T13:25:34Z
dc.date.issued2010-08-01
dc.description.abstractDrug abuse among humans often begins during adolescence. Exposure to psychostimulants during this age period may have long-term consequences which can render the organism more susceptible to drug abuse and relapse later in life. It has been demonstrated that exposure to stress can promote relapse to drug use even after long periods of withdrawal. The reinstatement of conditioned place preference (CPP) is a useful animal model for studying relapse. In humans and animals, changes in tyrosine hydroxylase (TN) have been related to drug addiction. Our study examined whether amphetamine-induced CPP during adolescence could be reinstated by exposure to stress 1 (adolescence) and 30 (adulthood) days after the extinction test. We also investigated TH levels following the reinstatement of CPP. Our results showed that amphetamine-induced CPP during adolescence can be reinstated by stress exposure 1 day (P42, end of adolescence) but not 30 days after extinction (P71, adulthood). Moreover the reinstatement of AMPH-induced CPP by stress exposure occurred in the presence of decreased TH in the nucleus accumbens. In conclusion, our data add new evidence that neuroadaptations on TH may mediate relapse to drug-seeking behavior induced by stress within adolescence. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista UNESP, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 São Paulo, Brazil
dc.description.affiliationUFSCar UNESP, Interinst Grad Program Physiol Sci, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 São Paulo, Brazil
dc.description.affiliationUnespUFSCar UNESP, Interinst Grad Program Physiol Sci, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 04/01606-0
dc.format.extent160-165
dc.identifierhttp://dx.doi.org/10.1016/j.pbb.2010.05.001
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V. Ltd, v. 96, n. 2, p. 160-165, 2010.
dc.identifier.doi10.1016/j.pbb.2010.05.001
dc.identifier.issn0091-3057
dc.identifier.lattes2514762545280942
dc.identifier.lattes7920438802539727
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.urihttp://hdl.handle.net/11449/8119
dc.identifier.wosWOS:000279627000008
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.relation.ispartofjcr2.538
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAmphetamineen
dc.subjectStressen
dc.subjectConditioned place preferenceen
dc.subjectReinstatementen
dc.subjectAdolescenceen
dc.subjectRaten
dc.titleStress-induced reinstatement of amphetamine-conditioned place preference and changes in tyrosine hydroxylase in the nucleus accumbens in adolescent ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes7920438802539727
unesp.author.lattes2514762545280942[4]
unesp.author.orcid0000-0002-1378-6327[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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