Influence of the single or combined administration of cocaine and testosterone in autonomic and neuroendocrine responses to acute restraint stress

Página do item simplificado
dc.contributor.authorCruz, Fabio C. [UNESP]
dc.contributor.authorEngi, Sheila A. [UNESP]
dc.contributor.authorLeao, Rodrigo M. [UNESP]
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:25:32Z
dc.date.available2014-05-20T13:25:32Z
dc.date.issued2012-10-01
dc.description.abstractAbuse of cocaine and androgenic-anabolic steroids (AASs) has become a serious public health problem. Despite reports of an increase in the incidence of simultaneous abuse of these substances, potential toxic interactions between cocaine and AASs are poorly known. In the present study, we investigated the effects of either single or combined administration of testosterone and cocaine for one or 10 consecutive days on autonomic (arterial pressure, heart rate and tail cutaneous temperature) and neuroendocrine (plasma corticosterone) responses induced by acute restraint stress in rats. Combined administration of testosterone and cocaine for 10 days reduced the increase in heart rate and plasma corticosterone level, as well as the fall in tail skin temperature induced by restraint stress. Furthermore, repeated administration of cocaine inhibited the increase in arterial pressure observed during restraint, and this effect was not affected by coadministration of testosterone. Ten-day combined administration of testosterone and cocaine increased basal values of arterial pressure. Moreover, chronic administration of testosterone induced rest bradycardia and elevated basal level of plasma corticosterone. One-day single or combined administration of the drugs did not affect any parameter investigated. In conclusion, the present study demonstrated that combined administration of testosterone and cocaine changed the autonomic and neuroendocrine responses to acute restraint stress. These findings suggest that interaction between AASs and cocaine may affect the ability to cope with stressful events.en
dc.description.affiliationSão Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationJoint UFSCar UNESP Grad Program Physiol Sci, São Carlos, SP, Brazil
dc.description.affiliationJoint UFSCar UNESP Grad Program Physiol Sci, Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespJoint UFSCar UNESP Grad Program Physiol Sci, São Carlos, SP, Brazil
dc.description.affiliationUnespJoint UFSCar UNESP Grad Program Physiol Sci, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPADC-School of Pharmaceutical Sciences-São Paulo State University
dc.description.sponsorshipIdFAPESP: 10/16192-8
dc.description.sponsorshipIdCNPq: 474177/2010-6
dc.format.extent1366-1374
dc.identifierhttp://dx.doi.org/10.1177/0269881112453210
dc.identifier.citationJournal of Psychopharmacology. London: Sage Publications Ltd, v. 26, n. 10, p. 1366-1374, 2012.
dc.identifier.doi10.1177/0269881112453210
dc.identifier.issn0269-8811
dc.identifier.lattes2514762545280942
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.urihttp://hdl.handle.net/11449/8097
dc.identifier.wosWOS:000308578300008
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofJournal of Psychopharmacology
dc.relation.ispartofjcr4.738
dc.relation.ispartofsjr1,939
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAbuseen
dc.subjectanabolic steroidsen
dc.subjectandrogensen
dc.subjectcocaineen
dc.subjectinteractionen
dc.subjectstressen
dc.subjectcardiovascularen
dc.subjectHPA axisen
dc.subjectglucocorticoidsen
dc.titleInfluence of the single or combined administration of cocaine and testosterone in autonomic and neuroendocrine responses to acute restraint stressen
dc.typeArtigo
dcterms.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dcterms.rightsHolderSage Publications Ltd
unesp.author.lattes1117432571971568[5]
unesp.author.lattes2514762545280942[4]
unesp.author.orcid0000-0002-1942-858X[5]
unesp.author.orcid0000-0002-1378-6327[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR
Artigos - Fisiologia e Patologia - FOAR